CYP2A6 Longitudinal Effects in Young Smokers

Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco
Dale S CannonRobert B Weiss

Abstract

The present study sought to identify time-dependent within-participant effects of CYP2A6 genotypes on smoking frequency and nicotine dependence in young smokers. Predicted nicotine metabolic rate based on CYP2A6 diplotypes (CYP2A6 diplotype predicted rate [CDPR]) was partitioned into Normal, Intermediate, and Slow categories using a metabolism metric. Growth-curve models characterized baseline and longitudinal CDPR effects with data from eight longitudinal assessments during a 6-year period (from approximately age 16-22) in young smokers of European descent (N = 296, 57% female) who had smoked less than 100 cigarettes lifetime at baseline and more than that amount by Year 6. Phenotypes were number of days smoked during the previous 30 days and a youth version of the Nicotine Dependence Syndrome Scale (NDSS). A zero-inflated Poisson growth-curve model was used to account for the preponderance of zero days smoked. At baseline, Intermediate CDPR was a risk factor relative to both Normal and Slow CDPR for smoking frequency and the NDSS. Slow CDPR was associated with the highest probability of smoking discontinuation at baseline. However, due to CDPR time trend differences, by young adulthood these baseline effects had been reordere...Continue Reading

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Aug 15, 2013·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Dale S CannonRobert B Weiss
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Citations

Nov 7, 2015·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Dale S CannonRobert B Weiss
Dec 30, 2016·Addiction Biology·Emily OlfsonLaura J Bierut
Apr 27, 2016·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·James W BaurleyAndrew W Bergen

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