Abstract
The purpose of this study was to investigate the frequency of CYP2B6 polymorphisms and their influence on plasma concentrations of efavirenz and nevirapine in HIV-infected Chinese patients. After written informed consent, 159 patients were enrolled at Shanghai Public Health Clinical Center. Genotyping for 516 G>T, 785 A>G, 983 T>C, and 1459 T>C polymorphisms in CYP2B6, together with CYP3A4 -392 A>G, CYP3A5 6986 A>G, and ABCB1 (2677 G>T/A, 3435 C>T), were performed. Plasma efavirenz and nevirapine concentrations of 120 patients at steady state were assessed by high-performance liquid chromatography-mass spectrometry. The minor allele frequency for CYP2B6 516 G>T, 785 A>G, 983 T>C, and 1459 T>C was 0.16, 0.24, 0, and 0, respectively; and 0.07, 0.32, 0.15, and 0.35 for CYP3A4 -392 A>G, CYP3A5 6986 A>G, ABCB1 2677 G>T/A, and ABCB1 3435 C>T, respectively. Univariate analysis indicated associations between 516 G>T (P < 0.01) with efavirenz but not nevirapine plasma concentrations. None of other genetic variants was associated with plasma efavirenz or nevirapine concentrations. Although CYP2B6 516 G>T was associated with high plasma efavirenz concentrations, such an association was not evident with nevirapine in this Chinese patient p...Continue Reading
References
Feb 24, 2001·AIDS·C MarzoliniT Buclin
Jul 27, 2001·Pharmacogenetics·T LangU M Zanger
Jul 27, 2001·Pharmacogenetics·R EiseltL Wojnowski
Jul 31, 2001·Therapeutic Drug Monitoring·P VillaniM B Regazzi
Aug 16, 2002·Pharmaceutical Research·Elke StörmerDavid J Greenblatt
Jan 25, 2003·Clinical Pharmacology and Therapeutics·Chantal CsajkaThierry Buclin
Apr 5, 2003·The Journal of Pharmacology and Experimental Therapeutics·Bryan A WardZeruesenay Desta
Jun 10, 2003·Clinical Pharmacokinetics·Theodora E M S de Vries-SluijsMarchina E van der Ende
Sep 19, 2003·Lancet·J Brooks JacksonFrancis Mmiro
Jun 11, 2004·The Journal of Pharmacology and Experimental Therapeutics·Thomas LangUlrich M Zanger
Jun 15, 2004·Biochemical and Biophysical Research Communications·Kiyoto TsuchiyaShinichi Oka
Feb 17, 2005·The Annals of Pharmacotherapy·Michel DuongHenri Portier
Apr 13, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sonia Rodriguez-NovoaVincent Soriano
May 3, 2005·Pharmacogenetics and Genomics·Margalida RotgerUNKNOWN Swiss HIV Cohort Study
Aug 9, 2005·Clinical Pharmacology and Therapeutics·Lisa M AlmondSaye H Khoo
Oct 18, 2005·AIDS·Blai Coll, Carlos Alonso-Villaverde
Nov 4, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Félix GutiérrezAlberto Martín-Hidalgo
Nov 4, 2005·The Journal of Infectious Diseases·David W HaasRichard B Kim
Nov 8, 2005·Pharmacogenetics and Genomics·Kathrin KleinUlrich M Zanger
Jan 26, 2006·British Journal of Clinical Pharmacology·David BurgerRon van Schaik
Feb 24, 2006·Pharmacogenetics and Genomics·Jue WangMagnus Ingelman-Sundberg
Jul 4, 2006·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Su GuanShu-Feng Zhou
Aug 17, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·David W HaasUNKNOWN Adult AIDS Clinical Trials Group
Sep 5, 2006·Pharmaceutical Research·Su GuanShu-Feng Zhou
Sep 27, 2006·Pharmacogenetics and Genomics·Danxin WangWolfgang Sadée
Oct 19, 2006·Pharmacogenetics and Genomics·Alison A MotsingerDavid W Haas
Jan 20, 2007·Clinical Pharmacology and Therapeutics·M RotgerU M Zanger
Mar 14, 2007·HIV Medicine·S R PenzakH Masur
May 1, 2007·World Journal of Gastroenterology : WJG·Bing-Ying XuMing-Liang He
Aug 30, 2007·AIDS Research and Human Retroviruses·Masaaki TakahashiTsuguhiro Kaneda
Dec 20, 2007·AIDS·Akihiko SaitohStephen A Spector
Feb 19, 2008·The Journal of Antimicrobial Chemotherapy·Christoph WyenUNKNOWN German Competence Network for HIV/AIDS
Jul 3, 2008·The Journal of Antimicrobial Chemotherapy·José MoltóBonaventura Clotet
Feb 4, 2009·AIDS·Hiroyuki Gatanaga, Shinichi Oka
Feb 17, 2009·The Journal of Antimicrobial Chemotherapy·Geetha RamachandranSoumya Swaminathan
Feb 21, 2009·HIV Medicine·Tw MahunguA Owen
Feb 26, 2009·The Journal of Infectious Diseases·David W HaasGrant R Wilkinson
May 29, 2009·Clinical Pharmacology and Therapeutics·T W MahunguA Owen
Jun 3, 2009·HIV Medicine·Vicki PowersM Gompels
Jun 18, 2009·Therapeutic Drug Monitoring·Kin Wang ToShui Shan Lee
Sep 15, 2009·The Journal of Antimicrobial Chemotherapy·Omar JannehSaye H Khoo
Dec 19, 2009·Pharmacogenomics·Cinzia CiccacciLeonardo Palombi
Citations
Sep 3, 2011·Pharmacogenetics and Genomics·Juan Gonzalo RestrepoJosé A G Agúndez
Sep 8, 2011·Antimicrobial Agents and Chemotherapy·Almudena SánchezUNKNOWN Tormes Group
Dec 21, 2012·Antimicrobial Agents and Chemotherapy·Weerawat ManosuthiSomnuek Sungkanuparph
Feb 2, 2013·PloS One·Peng ZhuLi Su
Dec 12, 2012·Pharmacogenomics and Personalized Medicine·Rebecca Pavlos, Elizabeth J Phillips
Apr 20, 2011·Paediatric Drugs·B Ryan Phelps, Natella Rakhmanina
Oct 20, 2011·Pharmacogenomics·Kerry Reed, Amadeo M Parissenti
Apr 3, 2012·Pharmacogenomics·Jing LiRajeev K Mehlotra
Jun 19, 2014·Expert Opinion on Drug Metabolism & Toxicology·Pablo BarreiroVincent Soriano
Nov 26, 2015·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Gianluca RussoLars Lennart Gustafsson
Apr 5, 2012·British Journal of Clinical Pharmacology·Chonlaphat SukasemWasun Chantratita
Aug 8, 2015·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Giacomo Maria PaganottiVincenzo Vullo
Feb 13, 2013·Drug Metabolism and Pharmacokinetics·Chonlaphat SukasemWeerawat Manosuthi
Jun 25, 2015·PloS One·Xianmin MengWeimin Cai
Sep 20, 2016·Clinical Pharmacokinetics·Andrea CalcagnoStefano Bonora
Nov 3, 2017·Pharmacogenomics·Željka TomasMarijana Peričić Salihović
Dec 1, 2017·PloS One·Zhimi TanLijun Zhang
Mar 14, 2019·Molecular Genetics & Genomic Medicine·HariOm SinghRaman R Gangakhedkar
Jun 28, 2018·Pharmacological Reviews·Dhwanil A DalwadiJohn A Schetz
Jul 5, 2012·Pharmacological Reviews·Veronique MichaudMark A Wainberg
Feb 23, 2020·BMC Infectious Diseases·Lili DaiLijun Sun
May 16, 2018·HIV Medicine·F GuoT Li
Mar 25, 2021·Pharmacogenomics and Personalized Medicine·Monkgomotsi J MasengGiacomo M Paganotti