CYP2C9 allele variants in Chinese hypertension patients and healthy controls

Clinica Chimica Acta; International Journal of Clinical Chemistry
Bang-ning YuHong-Hao Zhou

Abstract

Cytochromes P450 (CYP) 2C9 are polymorphic enzymes which catalyze a wide spectrum of drugs. It is also responsible for the metabolism of arachidonic acid into EETs. EETs are known to be a vasoactive substance and play an important role in a hypertensive episode. Whether the genetic polymorphism of CYP2C9 will affect the vasoactive effect and consequently affect hypertension formation is still unknown. We investigated the association of CYP2C9*2, CYP2C9*3 and CYP2C9*6 with hypertension. Two hundred and thirty-nine hypertension patients and 265 healthy controls participated in our study. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to identify CYP2C9*2, CYP2C9*3 and CYP2C9*6. CYP2C9*2 and CYP2C9*6 were not detected in our study. The allelic frequency of CYP2C9*3 was 0.015 in hypertension patients in our study. In healthy controls, the allelic frequency of CYP2C9*3 was 0.049. Significant difference existed in CYP2C9*3 frequency between hypertension patients and healthy controls (0.015 for hypertension patients vs. 0.049 for healthy controls; chi2 = 9.728, P < 0.005, OR = 0.277, 95% CI: 0.118-0.651). Also, gender-dependent difference was observed. In females, CYP2C9*3 frequency of hypertens...Continue Reading

References

Oct 1, 1996·Pharmacogenetics·M J StubbinsC R Wolf
Nov 14, 1997·Pharmacogenetics·K NasuT Ishizaki
Jan 28, 1999·Biochemical and Biophysical Research Communications·U YasarF Sjöqvist
Oct 16, 1999·Nature·B FisslthalerR Busse
Mar 31, 2000·Trends in Pharmacological Sciences·J Quilley, J C McGiff
May 23, 2000·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Y SaiM Shou
May 25, 2001·European Journal of Clinical Pharmacology·E García-MartínJ A Agúndez
Oct 27, 2001·Circulation Research·I Fleming
Jan 5, 2002·American Journal of Clinical Dermatology·M Rademaker
Feb 2, 2002·Clinical Pharmacology and Therapeutics·Umit YasarMarja-Liisa Dahl
Mar 15, 2002·Journal of the American College of Surgeons·Arash Rafii TabriziBradley D Freeman
Jan 23, 2003·Clinical Pharmacokinetics·Janice B Schwartz
May 8, 2003·European Journal of Clinical Pharmacology·Pedro DoradoAdrián LLerena

❮ Previous
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Citations

May 2, 2006·Molecular Diagnosis & Therapy·Elena García-MartínJosé A G Agúndez
Aug 12, 2005·European Journal of Clinical Pharmacology·Xiumei HongXiping Xu
Aug 16, 2011·Acta Pharmacologica Sinica·Jung-woo BaeSeok-yong Lee
Jan 11, 2013·Current Opinion in Nephrology and Hypertension·Jorge Capdevila, Wenhui Wang
Aug 10, 2011·Current Opinion in Lipidology·Ingrid Fleming
Jan 22, 2008·Annals of Human Genetics·C Bertrand-ThiébaultS Visvikis-Siest
Oct 31, 2008·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Zhenyan FuYitong Ma
May 14, 2010·Future Cardiology·Richard L SeipGualberto Ruaño
Aug 31, 2011·Cardiology Research and Practice·Muhiddin A Ozkor, Arshed A Quyyumi
Jun 10, 2009·Expert Opinion on Drug Metabolism & Toxicology·Rüdiger Kaspera, Rheem A Totah
Sep 29, 2012·Metabolism: Clinical and Experimental·Jorge A Costa e Silva
Jan 23, 2010·Pharmacology & Therapeutics·Beshay N M Zordoky, Ayman O S El-Kadi
Jun 24, 2009·Prostaglandins & Other Lipid Mediators·Jeffrey J IliffNabil J Alkayed
Aug 6, 2008·Clinica Chimica Acta; International Journal of Clinical Chemistry·Ting-Liang WangSusan Tai
Jan 22, 2008·Trends in Cardiovascular Medicine·Ingrid Fleming
Mar 21, 2007·Clinica Chimica Acta; International Journal of Clinical Chemistry·Ling-Hong LiaoMadeline Wu
Oct 15, 2013·Basic & Clinical Pharmacology & Toxicology·Da-Peng DaiJian-Ping Cai
Jan 18, 2006·Clinica Chimica Acta; International Journal of Clinical Chemistry·Herng-Der ChernChun-Wen Cheng
Feb 7, 2015·British Journal of Clinical Pharmacology·L YangI B Wilkinson
Jun 22, 2016·Drug Metabolism and Pharmacokinetics·Lay Kek TehMohd Zaki Salleh
Jul 8, 2017·Pharmacogenomics·Alison Lh QuinnJames C Lee
Feb 24, 2006·Hypertension·Ingrid Fleming, Rudi Busse
Jan 15, 2015·Hypertension·John D Imig
Sep 27, 2012·Journal of Cardiovascular Pharmacology·Jeremy Bellien, Robinson Joannides
Nov 27, 2014·Current Opinion in Nephrology and Hypertension·Fan FanRichard J Roman
Sep 3, 2019·Physiological Research·J D Imig

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