CYP2D6 and Endoxifen in Tamoxifen Therapy: A Tribute to David A. Flockhart

Clinical Pharmacology and Therapeutics
T C Skaar, Zeruesenay Desta

Abstract

This issue of Clinical Pharmacology & Therapeutics (CPT) includes the Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline for using CYP2D6 genotyping to guide tamoxifen therapy for breast cancer patients. CYP2D6 metabolizes tamoxifen to its more active metabolite, endoxifen, and patients with reduced CYP2D6 activity have reduced circulating endoxifen concentrations. In this associated commentary, we recognize and honor the late Dr. David Flockhart, who began the research and made early fundamental discoveries on tamoxifen that have now resulted in this guideline.

References

Nov 1, 1977·The Journal of Endocrinology·V C JordanG Prestwich
Apr 28, 2004·Breast Cancer Research and Treatment·Michael D JohnsonTodd C Skaar
May 26, 2004·The Journal of Pharmacology and Experimental Therapeutics·Zeruesenay DestaDavid A Flockhart
Jan 6, 2005·Journal of the National Cancer Institute·Yan JinDavid A Flockhart
Dec 20, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Matthew P GoetzJames N Ingle
Sep 26, 2013·Clinical Pharmacology and Therapeutics·M A ProvinceUNKNOWN International Tamoxifen Pharmacogenomics Consortium
Aug 31, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Matthew P GoetzJames N Ingle

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