CYP2D6*4, CYP3A5*3 and ABCB1 3435T polymorphisms and drug-related falls in elderly people.

Pharmacy World & Science : PWS
Maren I BlonkTischa J M van der Cammen

Abstract

The objective of this study is to investigate the association between CYP2D6*4, CYP3A5*3 and ABCB1 3435T polymorphisms and drug-related falls. Multivariate logistic regression was performed in an existing database in order to study the association between falls history and CYP2D6*4, CYP3A5*3, ABCB1 3435T polymorphisms in patients using fall-risk-increasing CYP2D6, CYP3A5 and P-glycoprotein (gene product of ABCB1) substrates. No statistically significant increased fall risk was found in 'poor metabolizers' compared to 'extensive' and 'intermediate metabolizers' using fall-risk-increasing CYP2D6 substrates (Odds ratio (OR) = 2.2; 95% confidence interval (CI) 0.2-25.0), CYP3A5 substrates (OR = 0.9; 95% CI 0.2-3.3) and P-glycoprotein substrates (OR = 2.1; 95% CI 0.2-17.2). The hypothesis that 'poor metabolizers' have an increased fall risk was not confirmed. A larger study population is needed to confirm the potential association that was seen between CYP2D6*4 and ABCB1 3435T polymorphisms and drug-related falls.

References

Jan 27, 1999·Journal of the American Geriatrics Society·R M LeipzigM E Tinetti
Jan 27, 1999·Journal of the American Geriatrics Society·R M LeipzigM E Tinetti
May 5, 2000·The Cochrane Database of Systematic Reviews·L D GillespieB H Rowe
Nov 1, 2001·The Cochrane Database of Systematic Reviews·L D GillespieB H Rowe
Jan 5, 2002·Age and Ageing·T Masud, R O Morris
Aug 31, 2006·British Journal of Clinical Pharmacology·Nathalie van der VeldeTischa J M van der Cammen
Sep 14, 2006·Pharmacological Reviews·Sharon J Gardiner, Evan J Begg
Jan 30, 2007·Clinical Pharmacology and Therapeutics·L W Chinn, D L Kroetz

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Citations

Apr 10, 2013·American Journal of Therapeutics·Namita Vilas NasareSambit Nath Bhattacharya
Jun 1, 2012·Personalized Medicine·Namita Vilas NasareSambit Nath Bhattacharya

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