CYP2E1 phenotype in Mexican workers occupationally exposed to low levels of toluene

Toxicology Letters
Octavio Jiménez-GarzaMaurizio Manno

Abstract

CYP2E1, an inducible enzyme present in different human tissues, metabolizes several potentially toxic substances including many volatile organic compounds (VOCs). One indirect way to monitor exposure to VOCs may be, therefore, the assessment of CYP2E1 activity in vivo using the chlorzoxazone (CHZ) test. To compare CYP2E1 activity in two groups of workers: one with a known occupational exposure to VOCs (exposed group) and the other employed in administrative tasks at two universities (control group) from the city of León, Guanajuato, México. (1) Passive diffusion monitors were used to evaluate individual levels of exposure to toluene, benzene and ethylbenzene in 48 persons (24 tannery workers and 24 administrative controls) during a 8h work shift; (2) after 12h fasting 500mg CHZ, a selective probe for assessing CYP2E1 activity, was orally administered and, after 2h, a venous blood sample was collected for HPLC plasmatic quantitative determination of CHZ and its mean metabolite 6-hydroxychlorzoxazone. Toluene mean exposure levels were higher in the exposed group (2.86±2ppm vs. 0.05±0.005ppm; p<0.001). Also, in this group CYP2E1 activity was lower (p<0.05) and it decreased as the accumulated months of labor exposure increased (neg...Continue Reading

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Citations

Dec 27, 2013·Asian Journal of Andrology·Moosa FanibandBo A G Jönsson
May 13, 2015·Toxicology and Applied Pharmacology·Octavio Jiménez-GarzaArnulfo Albores
Dec 17, 2014·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Beatriz Fátima Alves de OliveiraSandra Hacon
Nov 7, 2016·Environmental Toxicology and Pharmacology·Alberto Thalison SilveiraIsarita Martins

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