CYP2J2 Molecular Recognition: A New Axis for Therapeutic Design.

Pharmacology & Therapeutics
Aditi DasHannah C Huff

Abstract

Cytochrome P450 (CYP) epoxygenases are a special subset of heme-containing CYP enzymes capable of performing the epoxidation of polyunsaturated fatty acids (PUFA) and the metabolism of xenobiotics. This dual functionality positions epoxygenases along a metabolic crossroad. Therefore, structure-function studies are critical for understanding their role in bioactive oxy-lipid synthesis, drug-PUFA interactions, and for designing therapeutics that directly target the epoxygenases. To better exploit CYP epoxygenases as therapeutic targets, there is a need for improved understanding of epoxygenase structure-function. Of the characterized epoxygenases, human CYP2J2 stands out as a potential target because of its role in cardiovascular physiology. In this review, the early research on the discovery and activity of epoxygenases is contextualized to more recent advances in CYP epoxygenase enzymology with respect to PUFA and drug metabolism. Additionally, this review employs CYP2J2 epoxygenase as a model system to highlight both the seminal works and recent advances in epoxygenase enzymology. Herein we cover CYP2J2's interactions with PUFAs and xenobiotics, its tissue-specific physiological roles in diseased states, and its structural fea...Continue Reading

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Citations

Dec 19, 2020·Scientific Reports·Liang Xu, Liao Y Chen
Mar 16, 2021·Frontiers in Physiology·Jinsheng Lai, Chen Chen
May 29, 2021·BioMed Research International·Hafiz Ishfaq AhmadSadaf Almas
May 28, 2021·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Jacqueline Wen Hui LeowEric Chun Yong Chan
Aug 10, 2021·Neurotoxicology·Daniela Silva-AdayaMaría E Gonsebatt
Jun 29, 2021·Nutrition Research Reviews·Yuqi GaoZhao Wang

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