CYP3A5 polymorphism affects the increase in CYP3A activity after living kidney transplantation in patients with end stage renal disease

British Journal of Clinical Pharmacology
Yosuke SuzukiHiroki Itoh

Abstract

It has been reported that cytochrome P450 (CYP)3A activity increases significantly in patients with end stage renal disease (ESRD) after kidney transplantation, with wide interindividual variability in the degree of increase. The aim of this study was to evaluate the influence of CYP3A5 polymorphism on the increase in CYP3A activity after living kidney transplantation, by measuring the plasma concentration of 4β-hydroxycholesterol. This prospective study recruited 22 patients with ESRD who underwent a first living kidney allograft transplantation, comprising 12 patients with CYP3A5*1 allele (CYP3A5*1/*1 or *1/*3) and 10 patients without CYP3A5*1 allele (CYP3A5*3/*3). No significant difference in estimated glomerular filtration rate over time was observed between patients with the CYP3A5*1 allele and patients without the CYP3A5*1 allele, suggesting that the degrees of recovery in renal function after living kidney transplantation were similar in the two groups. However, plasma concentrations of 4β-hydroxycholesterol on days 90 (57.1 ± 13.4 vs. 39.5 ± 10.8 ng ml(-1)) and 180 (55.0 ± 14.5 vs. 42.4 ± 12.6 ng ml(-1)) after living kidney transplantation were significantly higher in the presence of the CYP3A5*1 allele than in the abse...Continue Reading

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Citations

Jan 23, 2016·Clinical Pharmacology and Therapeutics·Kenta YoshidaShiew-Mei Huang
Nov 5, 2016·Progress in Lipid Research·Valentin MutembereziGiulio G Muccioli
Sep 21, 2017·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Kristine HoleEspen Molden
Aug 28, 2020·Frontiers in Pharmacology·Effrosyni MendrinouGeorge P Patrinos

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