Abstract
Atherosclerosis represents the process by which fibrous plaques are formed in the arterial wall, increasing its rigidity with a subsequent decrease in blood flow which can lead to several cardiovascular events. Seeing as vitamin K antagonists are involved in the pathogenesis of atherosclerosis, we decided to investigate whether polymorphisms in genes that influence vitamin K metabolism might have an impact in modulating the risk of plaque formation. In the current study we included adult patients admitted in the Clinical Municipal Hospital of Cluj-Napoca without any carotid or femoral plaques clinically visible at the initial investigation, and a five year follow-up was subsequently performed. We recorded the following patient characteristics: age at inclusion, gender, area of living, smoking, presence of carotid and/or femoral plaques at five years, ischemic heart disease, arterial hypertension, atrial fibrillation, heart failure, diabetes mellitus, obesity, dyslipidemia, drug (oral anticoagulants, antihypertensives, hypolipidemic, anti-diabetic) use and status for the following gene polymorphisms: VKORC1 1639 G>A, CYP4F2 1347 G>T and GGCX 12970 C>G. We observed that the major predictor of both carotid and femoral plaque forma...Continue Reading
References
Mar 6, 1997·Nature·G LuoG Karsenty
Mar 22, 2006·Circulation·Yibo WangRutai Hui
Dec 15, 2007·Journal of Nutritional Science and Vitaminology·Natsuko SogabeMasae Goseki-Sone
Apr 1, 2008·Vitamins and Hormones·Andrea A Garcia, Pieter H Reitsma
Mar 20, 2009·Molecular Pharmacology·Matthew G McDonaldAllan E Rettie
Feb 13, 2010·The Journal of Nutritional Biochemistry·Yusuke OhsakiMichio Komai
Mar 4, 2011·Atherosclerosis·Fanny HerissonYann Gouëffic
Apr 21, 2012·Advances in Nutrition·Elke TheuwissenCees Vermeer
Sep 7, 2012·PloS One·Leon J SchurgersChris P Reutelingsperger
Nov 20, 2012·Blood Cells, Molecules & Diseases·Anca Dana BuzoianuSorin Crişan
Mar 6, 2013·Journal of Ultrasound·A CasadeiP Conci
May 22, 2013·Arquivos de neuro-psiquiatria·Adriana B ConfortoRaul D Santos
Jun 19, 2013·European Journal of Clinical Pharmacology·Tudor Radu PopAnca Dana Buzoianu
Sep 28, 2013·Journal of Cardiovascular Pharmacology·Yu-Tao Zhang, Ze-Yao Tang
Jun 18, 2014·Oman Medical Journal·Margueritta S El AsmarElias J Arbid
Sep 29, 2015·Medicinal Chemistry·Aimilios KalampogiasDimitris Tousoulis
Oct 6, 2016·BioMed Research International·Yevhen I DubovykAlexander V Ataman
Jan 27, 2017·International Journal of Molecular Sciences·Eva Y G De VilderOlivier M Vanakker
Mar 25, 2017·Journal of Gastrointestinal and Liver Diseases : JGLD·Ioana GrozaMonica Acalovschi
Jun 24, 2017·Basic & Clinical Pharmacology & Toxicology·Aino Siltari, Heikki Vapaatalo
May 8, 2018·Medical Archives·Enisa Hodzic
Jul 28, 2018·BioMed Research International·Solmaz Akbari, Amir Alireza Rasouli-Ghahroudi
Aug 2, 2018·Research in Pharmaceutical Sciences·Zohreh HosseinkhaniKamran Mansouri
Nov 30, 2018·Genes·Laith N Al-EitanRame H Khasawneh
Jan 9, 2019·Hepatology International·Akash ShuklaShobna Bhatia
Jan 17, 2019·Nutrients·Mario CozzolinoSagar Nigwekar
Jun 20, 2019·International Journal of Molecular Sciences·Kotaro Azuma, Satoshi Inoue
Aug 20, 2019·Nature Reviews. Disease Primers·Peter LibbyEldrin F Lewis
Oct 5, 2019·Annals of the New York Academy of Sciences·Anjum DihingiaPrasenjit Manna
Nov 2, 2019·The Pharmacogenomics Journal·Masanobu TakeuchiShinya Ito
Apr 2, 2020·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Mario RojoLuis Abel Quiñones
Apr 25, 2020·Frontiers in Pharmacology·Angela RocoLuis Abel Quiñones