PMID: 8589841Aug 1, 1995Paper

CYP6B3: a second furanocoumarin-inducible cytochrome P450 expressed in Papilio polyxenes

Insect Molecular Biology
C F HungM A Schuler

Abstract

Cytochrome P450 monooxygenases in the larvae of Papilio polyxenes (black swallowtail) (Lepidoptera: Papilionidae) are capable of detoxifying linear and angular furanocoumarins found in their host plants. The CYP6B1 locus, which is transcriptionally induced in these larvae in response to xanthotoxin, encodes a P450 that principally metabolizes linear furanocoumarins such as xanthotoxin and bergapten. We have now cloned CYP6B3 cDNA derived from a second locus that is evolutionarily related to the CYP6B1 locus. Reverse transcription-PCR Southern analyses have demonstrated that CYP6B3 transcripts are expressed in response to a wider range of linear and angular furanocoumarins but at lower abundance than CYP6B1 transcripts. Whereas CYP6B1 transcripts are expressed at a low detectable level in uninduced control larvae and at high levels in xanthotoxin-induced larvae, CYP6B3 transcripts are nearly undetectable in control larvae and are highly induced by xanthotoxin and bergapten (linear furanocoumarins) as well as by angelicin and sphondin (angular furanocoumarins). The fact that these two CYP6B loci are differentially regulated by these four furanocoumarins indicates that P. polyxenes has adapted to the presence of the wide range of ...Continue Reading

References

Nov 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·M B CohenM R Berenbaum
Aug 11, 1994·Nucleic Acids Research·H PrapaipongM A Schuler
Sep 1, 1989·Journal of Chemical Ecology·M B CohenM A Schuler

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Citations

Jan 17, 2004·Archives of Biochemistry and Biophysics·Liping PanMary A Schuler
Feb 8, 2003·Biochimica Et Biophysica Acta·Rebecca A PetersenMary A Schuler
Feb 11, 1999·Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology·J G ScottZ Wen
Feb 11, 1999·Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology·M AmichotJ B Bergé
Jun 14, 2000·Insect Biochemistry and Molecular Biology·J L StevensR Feyereisen
Aug 3, 2001·Insect Biochemistry and Molecular Biology·W LiM A Schuler
Feb 26, 2004·Proceedings of the National Academy of Sciences of the United States of America·Xianchun LiMary A Schuler
Apr 25, 2002·Proceedings of the National Academy of Sciences of the United States of America·Claudia NaumannDietrich Ober
Oct 29, 1996·Proceedings of the National Academy of Sciences of the United States of America·C F HungM A Schuler
Mar 1, 1996·Plant Physiology·M R FrankM A Schuler
Feb 17, 1999·Annual Review of Entomology·R Feyereisen
Aug 24, 2006·Annual Review of Entomology·Xianchun LiMay R Berenbaum
May 26, 1998·Environmental Health Perspectives·L Lagadic, T Caquet
Nov 7, 2001·Pest Management Science·J G Scott, Z Wen
Oct 5, 2010·Biochimica Et Biophysica Acta·Mary A Schuler
Jan 1, 2008·Archives of Insect Biochemistry and Physiology·Shaoming HuangL B Brattsten
Nov 14, 2006·Insect Biochemistry and Molecular Biology·Lee WilloughbyPhillip J Daborn
May 3, 2006·Insect Biochemistry and Molecular Biology·J P DavidC Dauphin-Villemant
Feb 22, 2017·Annals of the New York Academy of Sciences·Kim L Vertacnik, Catherine R Linnen
Dec 18, 2001·Archives of Insect Biochemistry and Physiology·T L HarrisonM R Berenbaum
Jul 30, 2002·Insect Molecular Biology·Xianchun LiMary A Schuler
Jan 3, 2021·Current Opinion in Insect Science·Kai LuRensen Zeng

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