CYP7A1-rs3808607 and APOE isoform associate with LDL cholesterol lowering after plant sterol consumption in a randomized clinical trial

The American Journal of Clinical Nutrition
Dylan S MacKayPeter Jh Jones

Abstract

The benefits of plant sterols (PSs) for cholesterol lowering are hampered by large heterogeneity across individuals, potentially because of genetic polymorphisms. We investigated the impact of candidate genetic variations on cholesterol response to PSs in a trial that recruited individuals with high or low endogenous cholesterol synthesis, estimated by lathosterol to cholesterol (L:C) ratio. Mildly hypercholesterolemic adults preselected as possessing either high endogenous cholesterol synthesis (n = 24; mean ± SEM: L:C ratio = 2.03 ± 0.39 μmol/mmol) or low endogenous cholesterol synthesis (n = 39; mean ± SEM: L:C ratio = 0.99 ± 0.28 μmol/mmol) consumed 2 g PS/d or a placebo for 28 d by using a dual-center, single-blind, randomized crossover design. Cholesterol synthesis and change in cholesterol absorption were measured with stable isotopic tracers. Candidate single-nucleotide polymorphisms and apolipoprotein E (APOE) isoform were assessed by TaqMan genotyping assay. The cholesterol fractional synthesis rate was higher (P < 0.001) in participants with high endogenous cholesterol synthesis (mean ± SEM: placebo: 9.16% ± 0.47%; PSs: 9.74% ± 0.47%) than in participants with low endogenous cholesterol synthesis (mean ± SEM placebo:...Continue Reading

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Citations

Oct 24, 2019·Nutrients·Ismael San Mauro MartínJavier Andrés Blumenfeld Olivares
Aug 14, 2018·Nutrition Reviews·Peter J H JonesOliver Weingärtner
Mar 31, 2019·Current Cardiology Reports·Itzel Vazquez-VidalPeter J H Jones
May 1, 2021·International Journal of Molecular Sciences·Michal VrablikJaroslav A Hubacek
Aug 28, 2021·Nutrients·Andrea PoliFrancesco Visioli

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