Cystadenomas of the liver and extrahepatic bile ducts: Morphologic and immunohistochemical characterization of the biliary and intestinal variants

Annals of Diagnostic Pathology
Jorge Albores-SaavedraDonald E Henson

Abstract

Cystadenomas of the liver and extrahepatic bile ducts (EHBD) are uncommon but distinctive neoplasms whose terminology and epithelial phenotype have been a source of controversy. We reviewed 20 cases, 16 arising in the liver and 4 in the EHBD. Eighteen patients were women, with a mean age of 36.5 years. Eighteen tumors were multiloculated and 2 were unilocular. The tumor size ranged from 4 to 29 cm (average, 11 cm). The cyst fluid in 13 tumors was described as serous, in 2 as clear, in 2 others as hemorrhagic, and in 1 as serous and mucinous. Only in 2 tumors was the fluid described as mucinous. In 18 cystadenomas, the predominant epithelial lining consisted of a single layer of cuboidal or low-columnar nondysplastic cells similar to those of the gallbladder or bile ducts. This epithelial lining was strongly positive for cytokeratins 7 and 19, and focally positive for MUC1. Only 2 cystadenomas showed predominant intestinal differentiation characterized by mature goblet cells and columnar absorptive cells. These cells expressed CDX2, MUC2, and cytokeratin 20. Admixed with the goblet and columnar cells, there were serotonin-containing cells and Paneth cells. These 2 tumors showed extensive areas of high-grade dysplasia and invasiv...Continue Reading

References

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Citations

Feb 23, 2019·AJR. American Journal of Roentgenology·Sanaz JavadiKhaled M Elsayes
Jun 27, 2019·BMC Gastroenterology·Côme TholomierJean-Sebastien Pelletier
Nov 11, 2017·Journal of Medical Case Reports·Zubair AhmadArsalan Ahmed
Mar 17, 2019·International Journal of Molecular Sciences·Aldona Kasprzak, Agnieszka Adamek
Jan 1, 2021·Human Pathology·Susan Shyu, Aatur D Singhi
May 23, 2020·Cirugía española·Alberto Alejandro Marcacuzco QuintoIago Justo Alonso
Jul 24, 2021·Pathologica·Samantha SarcognatoMaria Guido
Sep 1, 2021·Molecular and Clinical Oncology·Anna PaspalaDimitrios Schizas
Oct 2, 2021·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Matthew H LeePerry J Pickhardt

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