Cystathionine β-Synthase-Derived Hydrogen Sulfide Correlates with Successful Aging in Mice

Rejuvenation Research
Zhihong LuQian Ding

Abstract

Although learning and memory decline are associated with aging, some older individuals show high cognitive function. The mechanism underlying successful aging is not clear, although augmented N-methyl-D-aspartate receptor-independent long-term depression (LTD) has been found in successfully aged rats. We hypothesized that metabotropic glutamate receptor dependent LTD (mGluR-LTD) is associated with successful aging in mice and explored its molecular mechanisms. We divided aged mice into impaired and unimpaired groups and examined mGluR-LTD in the hippocampus. We examined the role of hydrogen sulfide (H2S) in mGluR-LTD establishment in aged mice and investigated the requirement of protein synthesis and intracellular calcium levels. We assessed learning and memory of mice treated with sodium hydrogen sulfide (NaHS) using behavior tests. We found that unimpaired mice elicited larger mGluR-LTD that correlated with H2S production which was blocked by inhibiting cystathionine synthase. Enhanced H2S production of NaHS treatment augmented mGluR-LTD in impaired group. mGluR-LTD establishment required protein synthesis, as well as intracellular calcium, although NaHS treatment leads to reduced sensitivity to calcium chelator 1,2-bis(o-ami...Continue Reading

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Citations

Mar 12, 2020·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·M M YurinskayaM B Evgen'ev
Apr 8, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yanjie ZhangGuangdong Yang
Oct 7, 2021·The Biochemical Journal·Stephen E WilkieColin Selman

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Methods Mentioned

BETA
Protein Assay
Infrared Imaging

Software Mentioned

ImageJ
SPSS

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