Cystatin C- and creatinine-based equations in the assessment of renal function in HIV-positive patients prior to commencing Highly Active Antiretroviral Therapy

Annals of Clinical Biochemistry
Tebogo SeapeJaya A George

Abstract

We evaluated the accuracy and precision of creatinine- and cystatin C-based prediction equations for estimating glomerular filtration rate compared to measured glomerular filtration rate in an antiretroviral-naive human immunodeficiency virus population. The study population consisted of 100 treatment-naive HIV patients. Glomerular filtration rate was estimated using the Cockcroft-Gault, Modification of Diet in Renal Disease (MDRD) and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations, as well as cystatin C-based equations (CKD-EPIcystatin C, cystatin Cvan Deventer and CKD-EPIcombined)) compared to (51)Cr-EDTA plasma clearance-measured glomerular filtration rate. We calculated percentage bias, standard deviation of the differences, accuracy within 15 and 30% of measured glomerular filtration rate and sensitivity and specificity for predicting measured glomerular filtration rate <60 mL/min/1.73 m(2). Bias for all estimating glomerular filtration rate equations ranged from -9.4% to 38.4%. The CKD-EPIcombined without ethnicity correction factor equation had the least bias, 2.9% (-2.9 to 8.8). Bias was higher for the Modification of Diet in Renal Disease and CKD-EPI equation with the African-American ethnicity f...Continue Reading

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Citations

Jun 14, 2016·Case Reports in Nephrology·Caitlin S BrownErin N Frazee
Mar 24, 2018·Southern African Journal of HIV Medicine·Michael T Boswell, Theresa M Rossouw
Jul 4, 2015·Clinical Journal of the American Society of Nephrology : CJASN·Charlotte OsafoUNKNOWN H3Africa Kidney Disease Research Network Investigators as members of The H3Africa Consortium
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Sep 2, 2020·Current Opinion in Nephrology and Hypertension·Natalie Ebert, Michael G Shlipak
Jun 5, 2020·European Journal of Nutrition·Simone H CrouchAletta E Schutte
Oct 24, 2018·Southern African Journal of HIV Medicine·Edith PhalaneAletta E Schutte
Dec 21, 2016·Clinical Kidney Journal·Pedro CamposKarina Soto
Sep 1, 2018·Southern African Journal of HIV Medicine·Willem D F VenterCharles Feldman

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