Jun 14, 2014

Cystatin C, a novel indicator of renal function, reflects severity of cerebral microbleeds

BMC Neurology
Mi-Young OhByung-Woo Yoon

Abstract

Chronic renal insufficiency, diagnosed using creatinine based estimated glomerular filtration rate (GFR) or microalbumiuria, has been associated with the presence of cerebral microbleeds (CMBs). Cystatin C has been shown to be a more sensitive renal indicator than conventional renal markers. Under the assumption that similar pathologic mechanisms of the small vessel exist in the brain and kidney, we hypothesized that the levels of cystatin C may delineate the relationship between CMBs and renal insufficiency by detecting subclinical kidney dysfunction, which may be underestimated by other indicators, and thus reflect the severity of CMBs more accurately. Data was prospectively collected for 683 patients with ischemic stroke. The severity of CMBs was categorized by the number of lesions. Patients were divided into quartiles of cystatin C, estimated GFR and microalbumin/creatinine ratios. Ordinal logistic regression analysis was used to examine the association of each renal indicator with CMBs. In models including both quartiles of cystatin C and estimated GFR, only cystatin C quartiles were significant (the highest vs. the lowest, adjusted OR, 1.88; 95% CI 1.05-3.38; p = 0.03) in contrast to estimated GFR (the highest vs. the lo...Continue Reading

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Citations

Mentioned in this Paper

Ischemic Cerebrovascular Accident
Abnormal Renal Function
Kidney Function Tests
Creatinine
Albumin To Creatinine Protein Ratio Measurement
Kidney Failure
Chronic Kidney Insufficiency
Brain
Kidney
Renal Insufficiency

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