Cystatin C: Its role in pathogenesis of OSMF

Journal of Oral Biology and Craniofacial Research
P C Anila Namboodiripad

Abstract

Oral Submucous Fibrosis (OSF) is a chronic disorder characterized by fibrosis of the mucosa lining the upper digestive tract involving the oral cavity, oro- and hypopharynx and the upper third of the oesophagus. The alkaloids from areca nut are the most important chemical constituents biologically, in producing this lesion. These chemicals appear to interfere with the molecular processes of deposition and/or degradation of extracellular matrix molecules such as collagen. Increased collagen synthesis or reduced collagen degradation have been considered as a possible mechanism in the development of the disease. Increased and continuous deposition of extracellular matrix may also take place as a result of disruption of the equilibrium between matrix metalloproteinases (MMPs) and tissue inhibitors of matrix metalloproteinases (TIMP). Arecoline a product of areca nut was found to elevate Cystatin C mRNA (CST3) and protein expression in a dose-dependent manner. Cystatin C expression was significantly higher in OSF specimens and expressed mainly by fibroblasts, endothelial cells, and inflammatory cells. Cross-links between the molecules are essential for the tensile strength of collagen fibres. These areas are resistant to attack by c...Continue Reading

Citations

Jul 17, 2019·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Qian PengZhangui Tang
Jul 28, 2017·Korean Journal for Food Science of Animal Resources·Sivakumar Allur Subramaniyan, Inho Hwang
Jun 19, 2019·International Journal of Molecular Sciences·Yin-Hwa ShihYu-Hsin Tseng
Jan 10, 2020·Journal of Otolaryngology - Head & Neck Surgery = Le Journal D'oto-rhino-laryngologie Et De Chirurgie Cervico-faciale·Naman R RaoNewell W Johnson
Oct 4, 2020·International Journal of Molecular Sciences·Yen-Wen ShenTzong-Ming Shieh
May 27, 2021·Genetic Testing and Molecular Biomarkers·Jeneffar Roselin ChristopherAnupama Tadepalli
Jul 28, 2020·Journal of Oral Biology and Craniofacial Research·Naman R RaoWai-Kit Ming

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