Cysteine: a potential biomarker for obstructive sleep apnea

Chest
Fatima CintraDalva Poyares

Abstract

Obstructive sleep apnea (OSA) is a risk factor for a number of cardiovascular conditions. Although homocysteine (Hcy) and cysteine (Cys) are regarded as cardiovascular risk factors, few studies have analyzed Hcy and Cys plasma concentrations in patients with OSA. The aim of this study was to evaluate the role of Hcy and Cys in OSA in comparison with subjects without OSA and to determine the possible influence of obesity on these variables. Patients who submitted to polysomnography studies were recruited to engage in an 8-h fasting period for blood sample withdrawal, physical examination, ECG, and echocardiogram. A subgroup of lean patients with OSA (BMI < 25 kg/m(2)) were analyzed to rule out the influence of obesity. Fifteen patients were randomly assigned to participate in a continuous positive airway pressure (CPAP) protocol to assess the influence of OSA treatment on the obtained measurements. A total of 75 patients and 75 control subjects matched for age and sex were analyzed. The Cys plasma levels were higher in patients with OSA compared with control subjects (490.16 ± 67.00 μmol/L vs 439.81 ± 76.12 μmol/L, respectively, P < .01); however, the Hcy plasma levels did not differ between groups. Cys plasma levels were also h...Continue Reading

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Citations

Sep 11, 2013·Journal of the American College of Nutrition·Fabrizia BamontiGiuliana Cighetti
Dec 30, 2014·Pulmonary Medicine·Konstantinos ArchontogeorgisPaschalis Steiropoulos
Feb 26, 2015·Proceedings of the National Academy of Sciences of the United States of America·Daiki NakatsuMasayuki Murata
Jul 7, 2011·Chest·Saadah AlrajabChristopher Jenks
Feb 3, 2011·Chest·Judy L Shih, Atul Malhotra
Jul 17, 2012·Chest·Sydney B MontesiAtul Malhotra
Apr 17, 2013·European Journal of Clinical Investigation·Ian W Seetho, John P H Wilding
Feb 27, 2015·Sleep & Breathing = Schlaf & Atmung·Ivan Guerra de Araújo FreitasSérgio Tufik
May 16, 2020·Trends in Cardiovascular Medicine·Adriana LebkuchenLuciano F Drager
May 8, 2021·Revue des maladies respiratoires·B HauquiertE Deflandre

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