PMID: 9523802Apr 2, 1998Paper

Cysteine conjugate beta-lyase-dependent metabolism of compound A (2-[fluoromethoxy]-1,1,3,3,3-pentafluoro-1-propene) in human subjects anesthetized with sevoflurane and in rats given compound A

Anesthesiology
R A IyerM W Anders

Abstract

Sevoflurane undergoes Baralyme- or soda lime-catalyzed degradation in the anesthesia circuit to yield compound A (2-[fluoromethoxy]-1,1,3,3,3-pentafluroro-1-propene), which is nephrotoxic in rats and undergoes metabolism via the cysteine conjugate beta-lyase pathway in those animals. The objective of these experiments was to test the hypothesis that compound A undergoes beta-lyase-dependent metabolism in humans. Human volunteers were anesthetized with sevoflurane (1.25 minimum alveolar concentration, 3%, 2 l/min, 8 h) and thereby exposed to compound A. Urine was collected at 24-h intervals for 72 h after anesthesia. Rats, which served as a positive control, were given compound A intraperitoneally, and urine was collected for 24 h afterward. Human and rat urine samples were analyzed by 19F nuclear magnetic resonance spectroscopy and gas chromatography-mass spectrometry for the presence of compound A metabolites. Analysis of human and rat urine showed the presence of the compound A metabolites S-[2(fluoromethoxy)-1,1,3,3,3-pentafluoropropyl]-N-acetyl-L- cysteine, (E)- and (Z)-S-[2-(fluoromethoxy)-1,3,3,3-tetrafluoro-1-propenyl]-N-acetyl- L-cysteine, 2-(fluoromethoxy)-3,3,3-trifluoropropanoic acid, 3,3,3-trifluorolactic acid, and ...Continue Reading

References

Nov 1, 1987·Anesthesiology·D P StrumE I Eger
Sep 1, 1995·Anesthesia and Analgesia·L KandelJ Martin
Mar 1, 1994·Anesthesiology·C T GonsowskiR L Kerschmann
Mar 1, 1994·Anesthesiology·C T GonsowskiR L Kerschmann
Mar 1, 1996·Anesthesiology·E J FrinkB R Brown
Jan 1, 1996·Anesthesia and Analgesia·P G Duncan, W D Pope
Jul 1, 1996·Anaesthesia·I T MundayJ G Kenna
Jan 1, 1997·Anesthesia and Analgesia·E I EgerR B Weiskopf
Mar 1, 1997·Journal of Anesthesia·J L MartinE I Eger

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Citations

Oct 3, 2006·Current Opinion in Anaesthesiology·D H BremerichM Behne
Apr 16, 2005·Annual Review of Pharmacology and Toxicology·M W Anders
Nov 25, 2005·Anesthesiology·Evan D KharaschH Denny Liggitt
Nov 10, 2012·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Hilmi OrhanNico P E Vermeulen
Mar 29, 2001·European Journal of Anaesthesiology·C GoetersH Van Aken
May 20, 2003·Best Practice & Research. Clinical Anaesthesiology·Florian M Reichle, Peter F Conzen
Aug 23, 2002·Acta Anaesthesiologica Scandinavica·A Di FilippoG P Novelli
May 12, 2000·Environmental Health Perspectives·L H LashC S Scott
Dec 31, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·Evan D KharaschSengkeo Srinouanprachanh
Nov 1, 2007·Current Protocols in Toxicology·Lawrence H Lash
May 12, 2000·Environmental Health Perspectives·L H LashJ C Parker
Mar 18, 2020·Journal of Medicinal Chemistry·Benjamin M JohnsonNicholas A Meanwell

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