Cysteine, cystine or N-acetylcysteine supplementation in parenterally fed neonates

The Cochrane Database of Systematic Reviews
L M Soghier, L P Brion

Abstract

L-cysteine is thought to be a conditionally essential (i.e., essential under certain conditions) amino acid for neonates. It is a precursor of glutathione, an antioxidant that may reduce oxidation injury. The addition of cysteine to parenteral nutrition (PN) allows for the reduction of the amount of methionine in PN, thereby limiting hepatotoxicity, and acidifies the solution, thereby increasing calcium and phosphate solubility, and potentially improving bone mineralization. To determine the effects of supplementing parenteral nutrition with cysteine, cystine or its precursor N-acetylcysteine on neonatal growth and short and long-term outcomes. The standard search method of the Cochrane Neonatal Review Group was used. MEDLINE (1966-December 2005), EMBASE (1974-December 2005), the Cochrane Central Register of Controlled Trials (CENTRAL, The Cochrane Library, Issue 1, 2006) and recent abstracts (until December 2005) from the Society for Pediatric Research/American Pediatric Society, Eastern Society for Pediatric Research, and Society for Parenteral and Enteral Nutrition were searched. All randomized (RCTs) and quasi-randomized trials that examined the effects of cysteine, cystine or N-acetylcysteine supplementation of neonatal PN...Continue Reading

Associated Clinical Trials

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Citations

Dec 28, 2012·The New England Journal of Medicine·M Elizabeth Hartnett, John S Penn
Nov 16, 2010·Current Opinion in Clinical Nutrition and Metabolic Care·Shadi S YarandiThomas R Ziegler
Apr 28, 2018·Asia-Pacific Journal of Ophthalmology·Julia P Shulman, M Elizabeth Hartnett
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Jul 16, 2019·Seminars in Perinatology·Nicholas D Embleton, Chris H P van den Akker
Jan 23, 2021·Journal of Clinical Medicine·Mitsuru ArimaKoh-Hei Sonoda

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