Cysteine dietary supplementation reverses the decrease in mitochondrial ROS production at complex I induced by methionine restriction

Journal of Bioenergetics and Biomembranes
Alexia GómezGustavo Barja

Abstract

It has been described that dietary cysteine reverses many of the beneficial changes induced by methionine restriction in aging rodents. In this investigation male Wistar rats were subjected to diets low in methionine, supplemented with cysteine, or simultaneously low in methionine and supplemented with cysteine. The results obtained in liver showed that cysteine supplementation reverses the decrease in mitochondrial ROS generation induced by methionine restriction at complex I. Methionine restriction also decreased various markers of oxidative and non-oxidative stress on mitochondrial proteins which were not reversed by cysteine. Instead, cysteine supplementation also lowered protein damage in association with decreases in mTOR activation. The results of the present study add the decrease in mitochondrial ROS production to the various beneficial changes induced by methionine restriction that are reversed by cysteine dietary supplementation.

References

Apr 1, 1972·Journal of the American Geriatrics Society·D Harman
Dec 1, 1994·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·J P RichieJ A Zimmerman
Jun 8, 2001·Mechanisms of Ageing and Development·J M DhahbiS R Spindler
Aug 13, 2002·Journal of Bioenergetics and Biomembranes·Gustavo Barja
Mar 22, 2003·The Journal of Biological Chemistry·Ellen R TaylorMichael P Murphy
Dec 9, 2003·Amino Acids·P Di SimplicioD Di Giuseppe
Sep 18, 2004·Trends in Neurosciences·Gustavo Barja
Nov 5, 2004·The EMBO Journal·Nicola VahsenGuido Kroemer
May 28, 2005·Endocrinology·Ricardo Gredilla, Gustavo Barja
Apr 18, 2006·Mechanisms of Ageing and Development·Kyung-Jin Min, Marc Tatar
Jun 29, 2006·Annals of the New York Academy of Sciences·Alberto SanzGustavo Barja
Dec 1, 2006·Journal of Bioenergetics and Biomembranes·A SanzG Barja
May 6, 2009·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Liou SunJames M Harper
Jan 19, 2010·Nutrition·Amany K ElshorbagyCarmen E Perrone
Jul 8, 2011·Proceedings of the National Academy of Sciences of the United States of America·Allegra A PettiDavid Botstein
Sep 21, 2011·Proceedings of the National Academy of Sciences of the United States of America·Hadise KabilScott D Pletcher
Jul 24, 2012·Experimental Gerontology·Carmen E PerroneNorman Orentreich
Nov 17, 2012·Metabolism: Clinical and Experimental·Amany K ElshorbagyCarmen E Perrone
Mar 5, 2013·Experimental Gerontology·Ines Sanchez-Roman, Gustavo Barja
Jun 7, 2013·Biogerontology·Yuehua WeiYing Cai
Jun 14, 2013·Experimental Biology and Medicine·Sreenivasa MaddineniJohn P Richie
Aug 10, 2013·Metabolism: Clinical and Experimental·Virginia L MalloyNorman Orentreich
Oct 12, 2013·Mass Spectrometry Reviews·Eric D MerkleyNorma Frizzell

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Citations

Mar 21, 2016·Annals of the New York Academy of Sciences·R Scott McIsaacRochelle Buffenstein
Feb 27, 2016·Annals of the New York Academy of Sciences·Gene P AblesSailendra N Nichenametla
Aug 30, 2016·Ageing Research Reviews·Holly M Brown-Borg, Rochelle Buffenstein
Jan 25, 2018·Annals of the New York Academy of Sciences·Anna K ShovellerJohn P Cant
Feb 6, 2018·Annals of the New York Academy of Sciences·Zhen DongJohn P Richie
Apr 1, 2018·Molecular Nutrition & Food Research·Jie YinYulong Yin
Mar 7, 2020·Nutrients·Desiree WandersXiangming Ji
Mar 27, 2020·Frontiers in Aging Neuroscience·Mariona JovéReinald Pamplona
Mar 7, 2017·Oxidative Medicine and Cellular Longevity·Jeddidiah W D Griffin, Patrick C Bradshaw
Nov 19, 2020·Antioxidants·Mariona JovéReinald Pamplona
Feb 29, 2020·Ageing Research Reviews·Marta Gonzalez-FreireRafael de Cabo
Jun 13, 2021·Communications Biology·N Mota-MartorellR Pamplona

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