Cysteine-rich protein 61 (CCN1) mediates replicative senescence-associated aberrant collagen homeostasis in human skin fibroblasts

Journal of Cellular Biochemistry
Taihao QuanGary J Fisher

Abstract

Dermal fibroblasts produce a collagen-rich extracellular matrix, which confers mechanical strength and resiliency to human skin. During aging, collagen production is reduced and collagen fragmentation is increased, which is initiated by matrix metalloproteinase-1 (MMP-1). This aberrant collagen homeostasis results in net collagen deficiency, which impairs the structural integrity and function of skin. Cysteine-rich protein 61 (CCN1), a member of the CCN family, negatively regulates collagen homeostasis, in primary human skin dermal fibroblasts. As replicative senescence is a form of cellular aging, we have utilized replicative senescent dermal fibroblasts to further investigate the connection between elevated CCN1 and aberrant collagen homeostasis. CCN1 mRNA and protein levels were significantly elevated in replicative senescent dermal fibroblasts. Replicative senescent dermal fibroblasts also expressed significantly reduced levels of type I procollagen and increased levels of MMP-1. Knockdown of elevated CCN1 in senescent dermal fibroblasts partially normalized both type I procollagen and MMP-1 expression. These data further support a key role of CCN1 in regulation of collagen homeostasis. Elevated expression of CCN1 substanti...Continue Reading

References

Sep 26, 1995·Proceedings of the National Academy of Sciences of the United States of America·G P DimriO Pereira-Smith
Sep 6, 1994·Annals of the New York Academy of Sciences·L M Matrisian
Jun 1, 1994·The Journal of Investigative Dermatology·M A Weinstock
Nov 14, 1997·The New England Journal of Medicine·G J FisherJ J Voorhees
Mar 30, 1999·Experimental Cell Research·L F Lau, S C Lam
Jul 3, 1999·Molecular and Cellular Biochemistry·M R KhorramizadehA Ghahary
Mar 29, 2002·The Journal of Pathology·James J GoingW Nicol Keith
Nov 20, 2002·Archives of Dermatology·Gary J FisherJohn J Voorhees
Nov 26, 2002·Molecular and Cellular Biology·Fan-E MoLester F Lau
Apr 26, 2003·The Journal of Investigative Dermatology·Suzanne E G FligielJohn J Voorhees
May 2, 2003·Nature Reviews. Cancer·Judith Campisi
May 24, 2003·American Journal of Clinical Dermatology·Nicholas J Raine-FenningYves Muscat-Baron
Aug 9, 2003·The Journal of Endocrinology·D R Brigstock
Jan 16, 2004·Lancet·Bernard Perbal
May 18, 2004·The Journal of Biological Chemistry·Johanna JokinenJyrki Heino
Nov 16, 2004·Mechanisms of Ageing and Development·Vincent J CristofaloMaria Tresini
Dec 8, 2004·The Journal of Biological Chemistry·Taihao QuanGary J Fisher
Nov 30, 2006·Journal of Cell Science·Andrew Leask, David J Abraham
Apr 30, 2008·British Journal of Cancer·J VaraniJ J Voorhees
May 21, 2008·Archives of Dermatology·Gary J FisherJohn J Voorhees
Sep 9, 2008·The International Journal of Biochemistry & Cell Biology·Chih-Chiun Chen, Lester F Lau
Aug 14, 2009·The Journal of Investigative Dermatology. Symposium Proceedings·Taihao QuanGary J Fisher
Mar 8, 2011·Experimental Cell Research·Anita BrandlPeter Angele

❮ Previous
Next ❯

Citations

Dec 24, 2013·International Journal of Pharmaceutics·Martha L Vázquez-GonzálezJordi Hernández-Borrell
Aug 22, 2013·The Journal of Investigative Dermatology·Si Young ChoSang-Jun Lee
Nov 1, 2015·Cellular Signalling·Erawan Borkham-KamphorstRalf Weiskirchen
Apr 5, 2013·Journal of Cellular Biochemistry·Shr-Jeng Jim LeuJeng-Jung Wang
Mar 4, 2014·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Harris PratsinisDimitris Kletsas
Jun 22, 2016·Placenta·Elizabeth A BonneyRamkumar Menon
Oct 21, 2016·Redox Biology·Ashish Kurundkar, Victor J Thannickal
Feb 20, 2018·Journal of Cell Communication and Signaling·Megan A ColeGary J Fisher
Sep 11, 2017·Journal of Cell Communication and Signaling·Chunji QuanTaihao Quan
Oct 18, 2018·Experimental Dermatology·Pauline HenrotMuriel Cario
Feb 23, 2020·Scientific Reports·Linling JuZhaolian Bian
Mar 28, 2020·Nutrients·Changwei CaoChangrong Ge
Mar 8, 2020·The FEBS Journal·Naama LeviValery Krizhanovsky
Jul 30, 2019·Frontiers in Pharmacology·Concepcion ParradoAngeles Juarranz
Jun 17, 2020·Ageing Research Reviews·Alexander Fedintsev, Alexey Moskalev

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.