Cysteinyl Leukotrienes (CysLTs): Role in Obesity-Induced Asthma

Current Molecular Medicine
U C S Yadav, S K Srivastava

Abstract

Epidemiological studies associate obesity with onset of asthma, especially in obese children, suggesting obesity as the risk factor for asthma. Obesity-induced chronic inflammation has been implicated in the lung inflammation, yet specific mediators and mechanisms are lacking. Obesity is associated with increased expression of 5-lipoxygenase (5-LO) pathway and increased Leukotrienes (LTs) production has been observed in obese asthma patients. However, the precise mechanism that predisposes lungs inflammation in obese is not clearly understood. This article discusses the production and regulation of LTs in obese individuals and presents probable mechanisms regarding the role of LTs in lung inflammation that may lead to obesity-induced asthma. Leukotrienes are well known mediators of asthma but their role in obesity-induced asthma is not clearly understood and thus needs further research. Since efficient antagonists and inhibitors of 5-LO pathways are known, understanding of molecular mechanism of LTs, especially Cysteinyl-LTs, in obesity-induced asthma could lead to optimal treatment regimens for the prevention and treatment of asthma in obese individuals.

Citations

Jan 27, 2019·Annals of the American Thoracic Society·Jason E LangJohn J Lima
Jun 24, 2017·Journal of Oral Science·Hossam AsaadOmar Kujan
Dec 15, 2016·Asthma Research and Practice·Cottini Marcello, Lombardi Carlo
Nov 30, 2019·Canadian Respiratory Journal : Journal of the Canadian Thoracic Society·Yiping LinYunguang Wang
Nov 3, 2020·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Neeraj DholiaUmesh C S Yadav
Jan 30, 2021·Obesity Research & Clinical Practice·Jiten R Sharma, Umesh C S Yadav

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Related Papers

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
A P Sampson
Journal of Lipid Research
Olof Rådmark, Bengt Samuelsson
Biochemical and Biophysical Research Communications
Olof Rådmark, Bengt Samuelsson
© 2021 Meta ULC. All rights reserved