Cysteinyl-tRNA formation and prolyl-tRNA synthetase

FEBS Letters
Clarisse Jacquin-BeckerConstantinos Stathopoulos

Abstract

Aminoacyl-tRNA (AA-tRNA) formation is a key step in protein biosynthesis. This reaction is catalyzed with remarkable accuracy by the AA-tRNA synthetases, a family of 20 evolutionarily conserved enzymes. The lack of cysteinyl-tRNA (Cys-tRNA) synthetase in some archaea gave rise to the discovery of the archaeal prolyl-tRNA (Pro-tRNA) synthetase, an enzyme capable of synthesizing Pro-tRNA and Cys-tRNA. Here we review our current knowledge of this fascinating process.

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Citations

Sep 6, 2012·Acta Crystallographica. Section D, Biological Crystallography·Eric T LarsonEthan A Merritt
Dec 11, 2003·Microbiology and Molecular Biology Reviews : MMBR·Patrick O'Donoghue, Zaida Luthey-Schulten
Mar 3, 2005·Proceedings of the National Academy of Sciences of the United States of America·Anurag SethiZaida Luthey-Schulten
Apr 16, 2003·Molecular Microbiology·Mette Praetorius-Ibba, Michael Ibba
Sep 8, 2016·Scientific Reports·Alejandro Manzano-Marín, Amparo Latorre
Apr 16, 2019·Toxicological Sciences : an Official Journal of the Society of Toxicology·Yasuhiro Shinkai, Yoshito Kumagai
Jul 20, 2002·The Journal of Biological Chemistry·Ivan AhelDieter Söll

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