PMID: 6409012Jan 1, 1983Paper

Cysteinyldopa isomers and dopa in lesions and urine of Japanese patients with malignant melanoma

Archives of Dermatological Research
T MorishimaS Hanawa

Abstract

Cysteinyldopas and Dopa in the urine and tissues of Japanese melanoma patients were investigated quantitatively by means of high-performance liquid chromatography. Cysteinyldopa isomers were detected in the urine of eumelanic Japanese patients. The amount (X +/- SD%) of each isomer of cysteinyldopa in the urine was 80.26 +/- 4.66% in 5-S-cysteinyldopa, 9.39 +/- 1.64% in 2-S-cysteinyldopa, 7.07 +/- 3.33% in 2, 5-S, S-dicysteinyldopa, and 3.28 +/- 1.43% in 6-S-cysteinyldopa. The amount of cysteinyldopa in melanoma tissues was 26-314 times more than that of Dopa. The amount (X +/- SD%) of cysteinyldopa in the tissues was 80.34 +/- 1.75% in 5-S-cysteinyldopa, 11.06 +/- 1.91% in 2-S-cysteinyldopa, 6.27 +/- 1.43% in 2, 5-S, S-dicysteinyldopa, and 2.34 +/- 0.61% in 6-S-cysteinyldopa. The fact that the percentages of each isomer of cysteinyldopa in the urine and in the tissues were approximately constant suggests that the cysteinyldopas secreted from melanoma cells were excreted into the urine without being metabolized.

References

Jan 1, 1976·Endeavour·G Prota, R H Thomson
Dec 15, 1976·Archives of Dermatological Research·E Paul, L Illig
Jul 1, 1980·The Journal of Investigative Dermatology·G Prota

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Citations

Jan 1, 1985·Archives of Dermatological Research·T Morishima, E Fukuda
Jul 15, 1985·Experientia·S ItoG Prota
Jul 1, 1989·Mayo Clinic Proceedings·R E Scott, D M Wilson
May 25, 2002·Pigment Cell Research·Kazumasa WakamatsuJonathan L Rees
May 25, 2002·Pigment Cell Research·Kazumasa Wakamatsu, Shosuke Ito
May 1, 1992·The British Journal of Dermatology·T NogitaT Morishima
Aug 1, 1987·Photochemistry and Photobiology·W H Koch, M R Chedekel
Apr 26, 2008·Photochemistry and Photobiology·Shosuke Ito, Kazumasa Wakamatsu
Nov 1, 1992·The Journal of Dermatology·S Ito
Jun 1, 1985·The Journal of Dermatology·T MorishimaN Nagashima
Oct 1, 1988·Medicinal Research Reviews·G Prota
Sep 3, 2003·Pigment Cell Research·Akihiko TakasakiBertil Kågedal
Jan 31, 2002·Journal of Chromatography. B, Biomedical Sciences and Applications·J Hartleb, R Arndt

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