Cystic fibrosis: a system for assessing and predicting progression

AJR. American Journal of Roentgenology
R H ClevelandA A Colin

Abstract

This study presents a radiography-based database scoring changes over time in a large population of patients with cystic fibrosis. The purpose of this database is to provide comparison for groups of patients undergoing experimental treatment to assess effect of the treatment. The data may also be used to compare individuals with their age-matched cohorts with cystic fibrosis. From 230 patients, 3038 chest radiographs were scored using the Brasfield system. The scores from radiographs from all the patients were individually plotted for age, and a single age-based severity curve was created. The age-based severity curve was compared with similar curves derived from pulmonary function studies of a subset of the same patient population. We found high inter- and intraobserver reliability. The difference between the observers averaged 1.3 Brasfield points, the scale of which ranges up to 25 points. The age-based severity curve was presented as mean Brasfield scores versus age (birth to > 30 years) plotted with 95% confidence limits; the curve was also plotted in percentiles. The rate of decline of this curve was similar to the decline of pulmonary function studies in this patient population. The age-based curve, a structural anatomic...Continue Reading

Citations

Jul 4, 2012·European Radiology·Kristina Vult von SteyernMats Geijer
Feb 2, 2006·Archives of Disease in Childhood·S JiménezJ Rodríguez
May 22, 2008·AJR. American Journal of Roentgenology·Filippo CademartiriGabriel P Krestin
Dec 3, 2009·Radiology·Robert H ClevelandAndrew A Colin
May 1, 2007·Clinics in Chest Medicine·Terry E Robinson
Dec 21, 2012·Pediatric Pulmonology·Gregory S SawickiLizheng Shi
Aug 19, 2010·Pediatric Pulmonology·Donald R VanDevanterMichael W Konstan
May 30, 2015·Pediatric Radiology·Robert H ClevelandCatherine Stamoulis
Jul 23, 2014·Pediatric Radiology·Jesiana Ferreira PedrosaRenata Marcos Bedran
Jun 2, 2004·Pediatric Pulmonology·Dubhfeasa M SlatteryRobert H Cleveland
May 15, 2003·Pediatric Pulmonology·Suzanne Terheggen-LagroCornelis van der Ent

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