Cystic fibrosis gene mutations do not affect sperm function during in vitro fertilization with micromanipulation for men with bilateral congenital absence of vas deferens

Fertility and Sterility
P N SchlegelZ Rosenwaks

Abstract

To assess the effects of cystic fibrosis transmembrane-conductance regulator (CFTR) gene mutations on sperm function and fertility in men with bilateral congenital absence of the vas deferens. Prospective. Division of urologic microsurgery and associated hospital-based IVF unit. Fertilization and pregnancy rates. Men referred to our fertility unit for treatment of bilateral congenital absence of the vas deferens, using sperm surgically retrieved from the epididymis with IVF and micromanipulation. Of 45 men with bilateral congenital absence of the vas, 54% (19/35) tested were found to be carriers of CFTR gene mutations, with one compound heterozygote. Epididymal sperm from men affected with CFTR mutations fertilized 19% (29/152) of oocytes, whereas men without mutations fertilized 22% (44/204) of oocytes. Pregnancy rates (PRs) were 36% (5/14) for cycles involving men with CFTR mutations and 33% (5/15) for other patients with congenital absence of the vas deferens but without detectable CFTR mutations. The presence of detectable CFTR mutations does not affect fertilization rates or PRs for men with bilateral congenital absence of the vas deferens when IVF and micromanipulation are applied.

Citations

Nov 16, 2004·The Journal of Urology·Jay D Raman, Marc Goldstein
Aug 12, 2014·Spermatogenesis·Matthew WosnitzerMatthew P Hardy
Aug 10, 2016·Current Urology Reports·Filipe Tenorio Lira NetoMarc Goldstein
Oct 31, 2019·Human Reproduction Update·Sean G BrownSarah J Martins da Silva
Mar 3, 2001·Human Reproduction·M V MengP J Turek
Oct 20, 2017·Reproduction : the Official Journal of the Society for the Study of Fertility·Zev Rosenwaks, Nigel Pereira
Jun 20, 2012·Human Reproduction Update·Hui ChenHsiao Chang Chan
Jul 17, 2007·Human Reproduction Update·UNKNOWN ESHRE Capri Workshop Group
Mar 25, 2005·Journal of Genetic Counseling·Elinor Langfelder-SchwindUNKNOWN National Society of Genetic Counselors Subcommittee on Cystic Fibrosis Carrier Testing
Feb 12, 2005·Reproductive Biomedicine Online·Mireille Claustres

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