Cystic fibrosis lung microbiome: opportunities to reconsider management of airway infection

Pediatric Pulmonology
Lindsay J CaverlyJohn J LiPuma

Abstract

The importance of infection in the pathogenesis of cystic fibrosis (CF) lung disease has been long recognized, and the use of antibiotics targeting bacteria identified in cultures of respiratory specimens has played a critical role in improving outcomes for individuals with CF. Over the past ∼15 years, the use of culture-independent methods to assess airway microbiology in CF has revealed complex and dynamic CF airway bacterial communities. Recent areas of investigation of the CF lung microbiome have included exploring how bacterial community structures change over time, particularly with respect to disease progression or pulmonary exacerbation, and in response to antibiotic therapies. This review will discuss what has been learned from these studies as well as how these findings offer opportunities to further refine management of CF airway infection.

Associated Clinical Trials

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Citations

May 9, 2016·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Lindsay J CaverlyJohn J LiPuma
Jul 30, 2016·Pediatric Clinics of North America·Edith T Zemanick, Lucas R Hoffman
Sep 24, 2016·Pediatric Pulmonology·Geraint B RogersLucas R Hoffman
Nov 23, 2016·Natural Product Reports·Neha GargVanessa V Phelan
Nov 2, 2017·Journal of Cellular Biochemistry·Macarena Massip-CopizTomás A Santa-Coloma
Aug 18, 2017·Pediatric Pulmonology·Katherine B FraymanSarath C Ranganathan
Aug 18, 2018·Expert Review of Respiratory Medicine·Lindsay J Caverly, John J LiPuma
Aug 5, 2017·Mycopathologia·A SinghA Hector
May 31, 2019·Clinical Microbiology Reviews·Sankalp MalhotraDaniel J Wozniak
Mar 30, 2017·Frontiers in Immunology·Carolyn D Kramer, Caroline Attardo Genco
Mar 2, 2016·American Journal of Respiratory and Critical Care Medicine·Edith T Zemanick, Claire Wainwright
Jun 16, 2017·American Journal of Respiratory and Critical Care Medicine·Timothy J Kidd
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Apr 30, 2017·Thorax·Jordana E Hoppe, Edith T Zemanick
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Sep 20, 2020·Toxicology Letters·Yanfeng XueXiangyang Kong
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