Cystic fibrosis: myths. mistakes, and dogma

Paediatric Respiratory Reviews
Bruce K Rubin

Abstract

As a student I recall being told that half of what we would learn in medical school would be proven to be wrong. The challenges were to identify the incorrect half and, often more challenging, be willing to give up our entrenched ideas. Myths have been defined as traditional concepts or practice with no basis in fact. A misunderstanding is a mistaken approach or incomplete knowledge that can be resolved with better evidence, while firmly established misunderstandings can become dogma; a point of view put forth as authoritative without basis in fact. In this paper, I explore a number of myths, mistakes, and dogma related to cystic fibrosis disease and care. Many of these are myths that have long been vanquished and even forgotten, while others are controversial. In the future, many things taken as either fact or "clinical experience" today will be proven wrong. Let us examine these myths with an open mind and willingness to change our beliefs when justified.

References

Feb 1, 1981·Pediatric Research·M King
May 1, 1997·The New England Journal of Medicine·S C FitzSimmonsA B Lowenfels
May 1, 1997·Journal of Pediatric Gastroenterology and Nutrition·Y YamashiroY Ohtsuka
Feb 19, 1999·Pediatric Pulmonology·B K Rubin
Dec 22, 1999·BMJ : British Medical Journal·D Isaacs, D Fitzgerald
Jan 14, 2000·The Journal of Hospital Infection·B JakobssonB Nyström
Mar 29, 2002·Pediatric Pulmonology·Michael Robinson, Peter T B Bye
Feb 28, 2004·American Journal of Respiratory Cell and Molecular Biology·Markus O HenkeBruce K Rubin
Aug 6, 2004·The European Respiratory Journal·D McShaneE W F W Alton
Sep 10, 2004·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Kristin G MonaghanGerald L Feldman
Aug 5, 2005·The New England Journal of Medicine·Lars Osterberg, Terrence Blaschke
Nov 4, 2005·The New England Journal of Medicine·Ronald J Campbell
Jan 3, 2006·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·Gameel N ZindaniSamya Z Nasr
Mar 25, 2006·American Journal of Respiratory and Critical Care Medicine·Ian M Balfour-LynnUNKNOWN CF WISE (Withdrawal of Inhaled Steroids Evaluation) Investigators
Feb 23, 2007·The New England Journal of Medicine·Peter M A CalverleyUNKNOWN TORCH investigators
Oct 31, 2007·Pediatric Pulmonology·S K KabraS Shastri
Feb 10, 2009·Chest·Judith A Voynow, Bruce K Rubin
May 27, 2009·Respiratory Care·Bruce K Rubin
Apr 9, 2011·Clinical Chemistry·Elizabeth M RohlfsElaine A Sugarman
Jun 8, 2011·Infection and Immunity·Markus O HenkeBruce K Rubin
Feb 1, 2013·Expert Review of Respiratory Medicine·Evangelia Daviskas, Bruce K Rubin

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Citations

Jan 15, 2014·Paediatric Respiratory Reviews·Dominic A Fitzgerald
Aug 1, 2018·Expert Opinion on Biological Therapy·Enrico Garaci

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