Cystic pancreatic neuroendocrine tumors (cPNETs): a systematic review and meta-analysis of case series.

Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva
Luis Hurtado-PardoJosé Luis Hernández Lizoain

Abstract

Cystic pancreatic neuroendocrine tumors represent 13% of all neuroendocrine tumors. The aim of this study is to analyze the phenotype and biologic behavior of resected cystic neuroendocrine tumors. A systematic review and meta-analysis were conducted until September 2016 using a search in Medline, Scopus, and EMBASE with the terms "cystic pancreatic endocrine neoplasm", "cystic islets tumors" and "cystic islets neoplasms". From the 795 citations recovered 80 studies reporting on 431 patients were selected. 87.1% (n = 387) were sporadic tumors and 10.3% (n = 40) corresponded to multiple endocrine neoplasia endocrine type 1. Were diagnosed incidentally 44.6% (n = 135). Cytology was found to have a sensitivity of 78.5%. Were non-functional tumors 85% (n = 338), and among the functional tumors, insulinoma was the most frequent. According to the European Neuroendocrine Tumor Society staging, 87.8% were limited to the pancreas (I-IIb), and 12.2% were advanced (III-IV). Disease-free survival at 5 years in stages (I-IIIa) and (IIIb-IV) was 91.5% and 54.2%, respectively; and was significantly lower (p = 0.0001) in functional tumors. In patients with multiple endocrine neoplasia there was a higher incidence of functional (62.5%) and mult...Continue Reading

References

May 1, 1978·The American Journal of Medicine·R H CaplanR V Randall
Jun 1, 1992·International Journal of Pancreatology : Official Journal of the International Association of Pancreatology·C IaconoA Dagradi
Aug 1, 1992·Pathology, Research and Practice·S YagihashiK Nagai
Jan 1, 1990·Virchows Archiv. A, Pathological Anatomy and Histopathology·A von HerbayH F Otto
Mar 1, 1990·Pancreas·H DavtyanH A Reber
May 1, 1986·Journal of Surgical Oncology·J M StairS Balachandran
Jun 1, 1986·Ultraschall in der Medizin : Organ der Deutschen Gesellschaft für Ultraschall in der Medizin, [der] Österreichischen Gesellschaft für Ultraschall in der Medizin, [der] Schweizerischen Gesellschaft für Ultraschall in Medizin und Biologie·W HeidrichT Weber
Feb 1, 1984·Annals of Surgery·N W ThompsonW E Strodel
May 1, 1984·Southern Medical Journal·P W HoA F Hoge
May 1, 1984·AJR. American Journal of Roentgenology·A C PoganyE J Ring
Jan 10, 1998·AJR. American Journal of Roentgenology·S A SohaibG M Besser
Apr 18, 1998·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·C KotoulasA Karameris
Aug 24, 1999·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·K BrownJ Pickleman
Feb 22, 2001·Annals of Internal Medicine·J P Vandenbroucke
Jun 8, 2001·The American Journal of Surgical Pathology·B LigneauJ Y Scoazec
May 3, 2002·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Steven A AhrendtHenry A Pitt
Jun 18, 2002·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Kerby C ObergMarie-Rose M Akin
Aug 20, 2005·International Journal of Gastrointestinal Cancer·Hiroshi ImaokaAkio Yanagisawa
Nov 19, 2005·Scandinavian Journal of Gastroenterology·Gianluca TamagnoNicola Sicolo
Apr 4, 2006·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·B K P GohW K Wong
May 9, 2006·World Journal of Surgery·Maria A KouvarakiNancy D Perrier
Nov 28, 2007·Journal of Hepato-biliary-pancreatic Surgery·Masatoshi KajiwaraTaira Kinoshita
Dec 19, 2007·Journal of Medical Case Reports·Mirjana Sumarac-DumanovicAleksandra Pavlovic
Dec 25, 2007·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Marshall S BakerHenry A Pitt
May 27, 2008·Journal of the American College of Surgeons·Liliana BordeianouCarlos Fernández-del Castillo
Jan 21, 2009·Archives of Surgery·Adhish BasuKrishnan R Iyengar
Feb 10, 2009·Surgery Today·Roberto BallarinGiorgio Enrico Gerunda
Sep 19, 2009·Endocrine Pathology·Runjan Chetty, Ihab El-Shinnawy
Dec 10, 2009·World Journal of Gastroenterology : WJG·Radoje B ColovićStojan M Latincić
Feb 23, 2010·International Journal of Surgery·David MoherUNKNOWN PRISMA Group
Apr 28, 2010·Virchows Archiv : an International Journal of Pathology·Günter KlöppelDavid S Klimstra
May 5, 2010·Gastrointestinal Endoscopy·David L DiehlJinhong Li
Oct 6, 2010·Virchows Archiv : an International Journal of Pathology·Björn KonukiewitzGünter Klöppel
Mar 4, 2011·American Journal of Surgery·Kuang-Chun HuShou-Chuan Shih
Jun 23, 2012·The Journal of Clinical Endocrinology and Metabolism·Rajesh V ThakkerUNKNOWN Endocrine Society
Jul 31, 2012·Journal of Cancer Research and Therapeutics·Sanjay D DeshmukhMani Anand
Oct 18, 2012·The American Journal of Surgical Pathology·Aatur D SinghiBarish H Edil
Mar 8, 2013·Cirugía española·Franz Robert Apodaca-TorrezEdson José Lobo

❮ Previous
Next ❯

Citations

Jan 10, 2018·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·Modesto J VarasAgustí Balboa
Jul 6, 2018·Expert Review of Anticancer Therapy·Lingaku LeeRobert T Jensen
Dec 20, 2018·Clinical Journal of Gastroenterology·Federico Salom, Frédéric Prat
Nov 9, 2018·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·Luis Hurtado-PardoJosé Luis Hernández Lizoáin
Feb 10, 2018·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·Javier A CienfuegosJavier Antoñanzas
Nov 12, 2020·Hormones : International Journal of Endocrinology and Metabolism·Damiano GulloAntonino Belfiore

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adenoma, Islet Cell

Islet Cell Adenoma arises in the islet cells, which are insulin producing cells of the pancreas. These tumors can be either malignant or benign. Discover the latest research on Islet Cell Adenoma here.

Autoimmune Polyendocrine Syndromes

This feed focuses on a rare genetic condition called Autoimmune Polyendocrine Syndromes, which are characterized by autoantibodies against multiple endocrine organs. This can lead to Type I Diabetes.

Carcinoma, Islet Cell (Keystone)

Islet Cell Carcinoma or Pancreatic Neuroendocrine Tumours arise in the hormone producing cells of the pancreas. These tumors can be either malignant or benign. Discover the latest research on islet cell carcinoma in this feed.

Carcinoma, Islet Cell

Islet Cell Carcinoma or Pancreatic Neuroendocrine Tumours arises in the hormone producing cells of the pancreas. These tumors can be either malignant or benign. Discover the latest research on Islet Cell Carcinoma here.