Cystic pancreatic neuroendocrine tumors: outcomes of preoperative endosonography-guided fine needle aspiration, and recurrence during long-term follow-up

Endoscopy
Wiriyaporn RidtitidM Al-Haddad

Abstract

The role of endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) in the diagnosis and management of cystic pancreatic neuroendocrine tumors (PNETs) is unclear. We aimed to compare clinical/endosonographic characteristics of cystic with solid PNETs, determine diagnostic accuracy of preoperative EUS-FNA, and evaluate recurrence rates after resection. All patients with cystic or solid PNET confirmed by EUS-FNA between 2000 and 2014 were identified. A matched case-control study compared 50 consecutive patients with cystic PNETs with 50 consecutive patients with solid PNETs, matched by gender and age at diagnosis of index cystic PNET. We compared clinical/endosonographic characteristics, assessed diagnostic accuracy of preoperative EUS-FNA for identifying malignancy, and analyzed tumor-free survival of patients with cystic and solid PNETs. Cystic PNETs tended to be larger than solid PNETs (mean 26.8 vs. 20.1 mm, P = 0.05), more frequently nonfunctional (96 % vs. 80 %, P = 0.03), and less frequently associated with multiple endocrine neoplasia type 1 (10 % vs. 28 %, P = 0.04). With surgical pathology as reference standard, EUS-FNA accuracies for malignancy of cystic and solid PNETs were 89.3 % and 90 %, respectively; cystic ...Continue Reading

Citations

May 25, 2016·Surgery·Jordan M CloydGeorge A Poultsides
Jan 10, 2018·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·Modesto J VarasAgustí Balboa
Jul 6, 2018·Expert Review of Anticancer Therapy·Lingaku LeeRobert T Jensen
Mar 15, 2018·Clinical Journal of Gastroenterology·Uayporn KaosombatwattanaHidemi Goto
Mar 8, 2017·Clinical Case Reports·Hideki IzumiToshio Nakagohri
May 24, 2017·World Journal of Gastroenterology : WJG·Salvatore PaiellaLuca Landoni
Nov 1, 2017·World Journal of Gastroenterology : WJG·Ryota SagamiKazunari Murakami
Jul 28, 2019·Annals of Surgery·Laura MagginoUNKNOWN on the behalf on the Pancreas 2000 research group

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