CYSTM, a novel cysteine-rich transmembrane module with a role in stress tolerance across eukaryotes.

Bioinformatics
Thiago M Venancio, L Aravind

Abstract

Using sensitive sequence profile analysis, we identify a hitherto uncharacterized cysteine-rich, transmembrane (TM) module, CYSTM, found in a wide range of tail-anchored membrane proteins across eukaryotes. This superfamily includes Schizosaccharomyces Uvi15, Arabidopsis PCC1, Digtaria CDT1 and Saccharomyces proteins YDL012C and YDR210W, which have all been implicated in resistance/response to stress or pathogens. Based on the pattern of conserved cysteines and data from different chemical genetics studies, we suggest that CYSTM proteins might have critical role in responding to deleterious compounds at the plasma membrane via chelation or redox-based mechanisms. Thus, CYSTM proteins are likely to be part of a novel cellular protective mechanism that is widely active in eukaryotes, including humans. Supplementary data are available at Bioinformatics online.

References

Mar 20, 1995·Molecular & General Genetics : MGG·J K LeeS D Park
Sep 1, 1997·Nucleic Acids Research·S F AltschulD J Lipman
Jun 8, 2000·Current Topics in Cellular Regulation·S M Deneke
Jul 26, 2002·Nature·Guri GiaeverMark Johnston
Jan 7, 2003·The Journal of Biological Chemistry·Traude BeilharzTrevor Lithgow
Oct 17, 2003·Nature·Won-Ki HuhErin K O'Shea
Nov 14, 2003·Planta·Nicolas Sauerbrunn, Nikolaus L Schlaich
Dec 14, 2005·BMC Bioinformatics·Timo Lassmann, Erik L L Sonnhammer
Jun 6, 2007·Journal of Internal Medicine·G von Heijne
Feb 5, 2008·Current Opinion in Structural Biology·Sarah Perrett, Gary W Jones
Mar 19, 2008·Trends in Biotechnology·Arthur Wuster, M Madan Babu
Apr 19, 2008·Science·Maureen E HillenmeyerGuri Giaever

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Citations

Oct 7, 2015·Frontiers in Molecular Biosciences·Megha Agrawal, Abhijit Biswas
Jan 30, 2015·European Journal of Human Genetics : EJHG·Anastasios MastrokoliasWilleke M C van Roon-Mom
Feb 1, 2019·Plant Molecular Biology·Yang XuJinguang Huang

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Methods Mentioned

BETA
environmental stresses

Software Mentioned

JPRED
TMHMM
BLAST
HMMER3
PSI
JACKHMMER
KALIGN
HMMSEARCH

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