Cystoid macular edema in aphakia and pseudophakia after use of prostaglandin analogs

Seminars in Ophthalmology
D Lynn Halpern, Louis R Pasquale

Abstract

Prostaglandin analogs are powerful ocular hypotensive agents that may also be associated with a breakdown of the blood-retinal barrier and cystoid macular edema. The association is evident in pseudophakic or aphakic patients. This paper presents a case of unilateral latanoprost-associated clinical cystoid macular edema in a bilaterally pseudophakic patient; the only difference between the two eyes was the presence of a capsulotomy in the affected eye. We review the literature concerning prostaglandin analog-associated cystoid macular edema, as well as the evidence for prostaglandin analog-associated breakdown of the blood-retinal barrier. Although some evidence is suggestive of a connection between prostaglandin analogs and cystoid macular edema, many questions concerning the complex physiology of prostanoids remain. Until our understanding of these issues is more advanced, judicious use of prostaglandin analogs in patients at risk for cystoid macular edema would be prudent.

References

Dec 31, 1997·American Journal of Ophthalmology·J A RoweD C Herman
Jul 31, 1998·American Journal of Ophthalmology·D CallananJ A Savage
Oct 21, 1998·American Journal of Ophthalmology·R S AyyalaD W Richards
Nov 18, 1998·Ophthalmology·J E ThorneR Lanciano
Jan 30, 1999·The British Journal of Ophthalmology·D R Wardrop, P K Wishart
Jun 10, 2000·Current Opinion in Ophthalmology·R A SchumerA K Mandahl
Sep 22, 2001·Journal of Cataract and Refractive Surgery·M WandM B Shields
Feb 28, 2002·American Journal of Ophthalmology·Martin Wand, Alexander R Gaudio

❮ Previous
Next ❯

Citations

Nov 16, 2010·Journal of Ophthalmology·Negin Agange, Sameh Mosaed
Jan 2, 2014·Therapeutic Advances in Chronic Disease·Deepak Sambhara, Ahmad A Aref
May 4, 2013·Drugs·Olga E MakriConstantine D Georgakopoulos
Nov 16, 2007·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Salomon Esquenazi
Nov 7, 2019·Vestnik oftalmologii·V P ErichevJ V Kosova
Oct 14, 2017·Ocular Immunology and Inflammation·M Reza Razeghinejad

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.