Cysts mark the early stage of metastatic tumor development in non-small cell lung cancer

Oncotarget
Chitra ThakurThomas Rudel

Abstract

Identifying metastatic tumor growth at an early stage has been one of the biggest challenges in the treatment of lung cancer. By genetic lineage tracing approach in a conditional model of Non-Small Cell Lung Cancer (NSCLC) in mice, we demonstrate that cystic lesions represent an early stage of metastatic invasion. We generated a mouse model for NSCLC which incorporated a heritable DsRed fluorescent tag driven by the ubiquitous CAG promoter in the alveolar type II cells of the lung. We found early cystic lesions in a secondary organ (liver) that lacked the expression ofbona fidelung makers namely Scgb1a1 and surfactant protein C Sftpc and were DsRed positive hence identifying lung as their source of origin. This demonstrates the significant potential of alveolar type II cells in orchestrating the process of metastasis, rendering it as one of the target cell types of the lung of therapeutic importance in human NSCLC.

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Citations

Jul 26, 2018·Artificial Cells, Nanomedicine, and Biotechnology·Xin WangXue-Tao Li
Aug 23, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Hong-Jun XieTashi Tsering

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Methods Mentioned

BETA
transgenic
flow cytometry
FACS
PCR
genotyping

Software Mentioned

Graphpad Prism
AxioVision
Graphpad

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