Cytidine decreases melanin content in a reconstituted three-dimensional human epidermal model

Archives of Dermatological Research
Sudhir M BaswanJohn Pawelek

Abstract

The process of melanin biosynthesis and its distribution throughout the skin is regulated by complex processes involving several enzymes in melanocytes. Recently, Diwakar et al. demonstrated that cytidine-a sialyltransferase inhibitor, 6'-sialyllactose (6'-SL) and 3'-sialyllactose (3'-SL) inhibited melanogenesis and melanosome transfer process. In this study, we have furthered this research, considering cytidine as a commercially viable and safe option over 6'-SL and 3'-SL. The efficacy of 2% w/v cytidine was studied in MelanoDerm™ skin equivalents in comparison with the positive control 1% w/v kojic acid and the vehicle control. Both the positive control and cytidine demonstrated a significant reduction in melanin content relative to the vehicle control. These experiments conclude that cytidine can effectively reduce melanin content in a skin equivalence assay and suggests that cytidine may be a good candidate for a skin lightening agent for human skin.

References

Jan 24, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Gertrude-E Costin, Vincent J Hearing
Oct 23, 2016·Pigment Cell & Melanoma Research·Bruno FernandesArtur Cavaco-Paulo

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Citations

Aug 21, 2020·International Journal of Dermatology·Kayla M BabbushAmor Khachemoune
Dec 19, 2020·Clinical, Cosmetic and Investigational Dermatology·Sudhir M BaswanNathan Stern

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