Cyto-, axo- and dendro-architectonic changes of neurons in the limbic system in the mouse pilocarpine model of temporal lobe epilepsy

Epilepsy Research
Feng Ru Tang, Weng Keong Loke

Abstract

While different hypotheses have been proposed to explain the mechanism of onset of temporal lobe epilepsy (TLE), most of them are based on structural, electrophysiological, cellular or molecular changes in one particular area. Extensive neuronal loss, axon reorganization, dendrite and dendritic spine growth make it impossible to apply one hypothesis to explain epileptogenesis for patients or animal models with different pathophysiological changes in the brain. It is therefore hypothesized that cyto-, axo- and dendro-architectonic changes at multiple brain regions may be involved in epileptogenesis in TLE. In the review, structural changes of the limbic system, in particular, hippocampus, entorhinal cortex, subiculum and amygdale, in the mouse pilocarpine model of TLE will be summarized. Their functional significance will be discussed. The final conclusion and future research directions will then be made.

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Citations

Feb 3, 2016·Frontiers in Neuroanatomy·Dong Liang MaFeng Ru Tang
Mar 10, 2016·Experimental Neurology·Ana Clara Silveira BrogginiRichardson Naves Leão
Jan 24, 2012·Experimental Neurology·Xiao-Xin YanPeter R Patrylo
Oct 18, 2014·Frontiers in Neuroanatomy·Kinga Tóth, Zsófia Maglóczky
Jan 30, 2014·Clinical Neuroradiology·A A CapizzanoT Moritani

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