Cytoarchitecture and intercalated disks of the working myocardium and the conduction system in the mammalian heart

The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology
Tatsuo ShimadaKana Sueda

Abstract

Working and specialized cardiac myocytes and their intercalated disks (ID) in the mammalian heart were examined by transmission and scanning electron microscopy. The NaOH/ultrasonication treatment of cardiac tissues resulted in the digestion of collagen fibers and separation of intercellular junctions. Auricular and ventricular myocytes were cylindrical in shape, bifurcated, and connected end-to-end at the ID. The ID in the working myocardium showed a stair-like profile, consisting of steps (plicate segments) and corresponding risers (interplicate segments). The ventricular myocytes had many steps and risers. The steps were filled with numerous finger-like microprojections, including desmosomes, fasciae adherentes, and small gap junctions. The risers showed the smooth surface, including desmosomes and large gap junctions. The cell strands of the sinoatrial node were oriented linearly, while those of the atrioventricular node formed a reticular network. The ID in both nodal cells was underdeveloped, having few microprojections. Myocytes in the His bundle and its branches were arranged in parallel, and Purkinje cell strands formed reticular networks. The ID in the His-Purkinje system was irregular in appearance, and the microproj...Continue Reading

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Citations

Apr 4, 2008·Histochemistry and Cell Biology·Jens Waschke
Apr 18, 2014·Cell Communication & Adhesion·Valeria MezzanoFarah Sheikh
Mar 14, 2009·Differentiation; Research in Biological Diversity·Augusto OrlandiChristine Chaponnier
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Apr 13, 2006·Nano Letters·Masataka Hakamada, Mamoru Mabuchi
Jul 16, 2021·The Journal of General Physiology·Nicolae MoiseSeth H Weinberg

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