PMID: 6977821Apr 1, 1981Paper

Cytochemistry and membrane markers in acute lymphatic leukaemia (ALL)

Scandinavian Journal of Haematology
D HuhnP Andreewa

Abstract

136 patients suffering from ALL were subdivided into 5 subtypes (C-ALL, C/T-ALL, pre-T-ALL, B-ALL) according to rosetting tests and using specific antisera directed against membrane antigens. In addition, leukaemic blasts of all patients were investigated according to morphological and cytochemical criteria. In APh and ANAE, indices and the percentages of cases showing a granular staining pattern were high in pre-T- and in T-ALL, but low in C/T- and in C-ALL. PAS-staining, conversely, was more pronounced in C/T- and C-ALL. APh proved to be more discriminative for recognition of the T- and pre-T-ALL subgroups than ANAE, but ANAE-cytochemistry may be useful to detect contaminating normal T-lymphocytes in ALL. Receptors for C3 were more frequent in C- and in T-ALL than in C/T- and in pre-T-ALL, receptors for Fc were distributed equally among all subtypes. Positively of C3- and Fc-receptors was not correlated with cytochemical results. Morphological criteria were not sufficient for subclassification of ALL; the combination of APh- and PAS-staining, however, is valuable to differentiate between C-subgroups and T-subgroups.

References

Jan 1, 1979·American Journal of Hematology·H R SchumacherS A Stass
Jan 1, 1979·Leukemia Research·G GaedickeG Landbeck
Jun 1, 1977·British Journal of Haematology·J KulenkampffM F Greaves
Apr 20, 1978·The New England Journal of Medicine·L B VoglerM D Cooper
Jul 15, 1978·Klinische Wochenschrift·D HuhnH Theml
Jan 1, 1979·American Journal of Hematology·R B RaneyH W Hann
Jan 1, 1979·Haematology and Blood Transfusion·H RodtS Thierfelder
Mar 15, 1976·International Journal of Cancer. Journal International Du Cancer·H SteinG Landbeck
Mar 1, 1974·American Journal of Clinical Pathology·G B HumphreyR D Brunning
Aug 1, 1974·Blut·F SchmalzlH Braunsteiner
Apr 15, 1972·Klinische Wochenschrift·D Huhn, F Schmalzl
Jul 1, 1974·Journal of Immunological Methods·M E Kaplan, C Clark

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