PMID: 16615671Apr 18, 2006Paper

Cytochrome-c oxidase inhibition in 26 aluminum phosphide poisoned patients

Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists
Surjit SinghKirandip Gill

Abstract

Aluminum phosphide (ALP) is used worldwide to fumigate grain. ALP poisoning, though reported from different parts of world, is most common in north, northwest and central India. In the presence of moisture, ALP liberates phosphine, which is highly toxic. The mechanism of action of phosphine is not known though experimental studies show that it inhibits cytochrome-c oxidase leading to inhibition of mitochondrial oxidative phosphorylation. We estimated cytochrome-c oxidase activity in platelets of patients who had ingested ALP and compared them with those in healthy controls and in patients with shock due to other causes (cardiogenic shock, septic shock and hemorrhagic shock). After analysis of variance using Kruskal-Wallis test followed by Mann Whitney U test, significant inhibition of cytochrome-c oxidase activity could be found in ALP-poisoned patients compared to healthy controls (z = -5.513, p < 0.001) and in patients with shock due to other causes (z = -2.344; p < 0.05). There was no significant difference in inhibition in those who survived ALP poisoning compared to those who died from ALP poisoning (t = 0.02768; p > 0.05). Though inhibition of cytochrome-c oxidase in platelets does not have prognostic value, it suggests t...Continue Reading

References

Feb 1, 1979·Journal of Occupational Medicine. : Official Publication of the Industrial Medical Association·R P Smith, R E Gosselin
Jan 1, 1990·Annual Review of Biochemistry·R A Capaldi
Apr 13, 1985·British Medical Journal·S SinghB K Sharma
Oct 5, 1970·Annals of the New York Academy of Sciences·R F Coburn
Jul 1, 1983·The Journal of Clinical Investigation·K KarimanH A Saltzman
Jan 1, 1996·Journal of Toxicology. Clinical Toxicology·S SinghB K Sharma
Sep 24, 2004·International Journal of Experimental Pathology·Hsiang-Wen ChenRei-Cheng Yang

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Citations

May 16, 2008·Human & Experimental Toxicology·S ShadniaM Abdollahi
Oct 16, 2009·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Kambiz SoltaninejadJeffrey Brent
May 25, 2011·Journal of Applied Toxicology : JAT·R AnandKiran Dip Gill
Oct 18, 2016·Arhiv za higijenu rada i toksikologiju·Behrooz Hashemi-DomenehAli Ostadi
Apr 4, 2020·Annals of the New York Academy of Sciences·Wing Y TuetBenjamin Wong
Nov 14, 2007·Toxicological Sciences : an Official Journal of the Society of Toxicology·Steven ZurynPaul Ebert
May 16, 2007·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Edward AmoresLewis S Nelson
Sep 10, 2015·Pacing and Clinical Electrophysiology : PACE·Mukund A PrabhuJayaprakash Shenthar
May 27, 2017·BMC Pharmacology & Toxicology·Nilukshana YogendranathanAruna Kulatunga
May 30, 2017·Archives of Toxicology·Mohammad Hossein AsghariMohammad Abdollahi
Feb 4, 2019·Basic & Clinical Pharmacology & Toxicology·Adeleh MalekiAhmad Reza Dehpour
Jul 20, 2019·Expert Opinion on Drug Metabolism & Toxicology·Omid MehrpourPatrick Ng
Nov 13, 2019·International Journal of Legal Medicine·Yue LiangYiwu Zhou
Jun 12, 2020·Journal of Clinical Pharmacy and Therapeutics·Zohereh OghabianSomayyeh Karami-Mohajeri
May 27, 2020·Cardiovascular Toxicology·Parinaz ParhizgarHossein Hassanian-Moghaddam
Jan 11, 2012·Journal of Intensive Care Medicine·Tze-Ming Benson ChenWare G Kuschner
Nov 9, 2010·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Babak MostafazadehMohammad Reza Rasouli
Dec 19, 2017·Inhalation Toxicology·Benjamin WongAlfred M Sciuto
Mar 5, 2020·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·A K PannuD P Dhibar
Mar 13, 2009·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Alex T Proudfoot
Oct 19, 2007·The Journal of Pharmacology and Experimental Therapeutics·Hélène GautierBruno Lapied
Apr 18, 2012·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Hossein Hassanian-Moghaddam, Afshin Shahbazi
Oct 3, 2008·Human & Experimental Toxicology·O MehrpourM Sedaghat
Nov 15, 2012·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Hiva TehraniMohammad Abdollahi
Jan 9, 2018·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·Ashish BhallaSurjit Singh
Oct 5, 2018·Arhiv za higijenu rada i toksikologiju·Nasim ZamaniSakine Ebrahimi
Feb 6, 2017·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·Maryam Vasheghani FarahaniSayed Mahdi Marashi
Jul 24, 2021·Toxicology and Applied Pharmacology·Wing Y TuetBenjamin Wong
Oct 30, 2021·Toxicology Mechanisms and Methods·Mohammad Reza Hooshangi ShayestehMohammad Abdollahi
Jan 16, 2022·Environmental Science and Pollution Research International·Nadia E HelalAmira A Wahdan

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