Cytochrome C suppresses renal accumulation and nephrotoxicity of polymyxin B

Human & Experimental Toxicology
Z-D LiM Liu

Abstract

The receptor megalin plays an important role in the accumulation of polymyxin B (PMB) in renal cells in vitro. This study aimed to examine the effects of cytochrome c (cyto c), a typical megalin ligand, on renal accumulation and nephrotoxicity of PMB in vivo. Thirty Sprague-Dawley rats were randomly divided into the vehicle control group, PMB group, PMB + cyto c 50, 100, or 200 mg/kg group, respectively, and were treated with intravenous cyto c 30 min before the administration of PMB 4.0 mg/kg once a day for consecutive 5 days. On the 4th day after administration, 24 h urine was collected to determine N-acetyl-β-D-glucosaminidase excretion. Six hours after the last injection on the 5th day, kidneys were harvested to assay PMB concentration and observe pathological alterations, and blood samples were collected to assay serum creatinine (SCr), blood urea nitrogen (BUN), and blood β2-microglobulin (β2-MG) levels. Cyto c 50, 100, and 200 mg/kg decreased the accumulation of PMB in the kidney by 18.5%, 39.1% ( p < 0.01), and 36.8% ( p < 0.01), respectively, and reduced 24 h N-acetyl-β-D- glucosaminidase excretion by 22.5% ( p < 0.05), 40.4% ( p < 0.01), and 40.4% ( p < 0.01), respectively. Kidney pathological damage induced by PMB wa...Continue Reading

References

Jan 1, 1977·Annual Review of Biochemistry·D R StormP E Swanson
Sep 1, 1995·The Journal of Clinical Investigation·S K MoestrupE I Christensen
Mar 17, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ayahisa WatanabeMikihisa Takano
Aug 30, 2005·Antimicrobial Agents and Chemotherapy·Vincent H TamRussell E Lewis
Mar 2, 2006·Critical Care : the Official Journal of the Critical Care Forum·Matthew E Falagas, Sofia K Kasiakou
Aug 26, 2006·The Lancet Infectious Diseases·Jian LiDavid L Paterson
Oct 3, 2009·Current Opinion in Infectious Diseases·Roger L Nation, Jian Li
Sep 21, 2010·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Chang ChengSteven Hansel
Dec 1, 2011·The Journal of Antimicrobial Chemotherapy·Jumana M YousefJian Li
Jun 13, 2012·Antimicrobial Agents and Chemotherapy·Kamilia AbdelraoufVincent H Tam
Aug 22, 2012·Antimicrobial Agents and Chemotherapy·Kamilia AbdelraoufVincent H Tam
Sep 11, 2012·Diagnostic Microbiology and Infectious Disease·Phillip J BergenJian Li
Jun 26, 2013·Antimicrobial Agents and Chemotherapy·Mohammad A K AzadJian Li
Oct 9, 2013·Antimicrobial Agents and Chemotherapy·Takahiro SuzukiKen Iseki
Apr 16, 2014·Antimicrobial Agents and Chemotherapy·Kamilia AbdelraoufVincent H Tam
Oct 24, 2015·The Journal of Antimicrobial Chemotherapy·Xiaoxi LuFanfan Zhou
Jun 22, 2016·Future Medicinal Chemistry·Tony VelkovJian Li
Dec 21, 2016·Antimicrobial Agents and Chemotherapy·Alexandre P Zavascki, Roger L Nation
Mar 25, 2018·Annals of Clinical Microbiology and Antimicrobials·Ritesh Aggarwal, Arun Dewan

❮ Previous
Next ❯

Citations

Mar 17, 2019·Antibiotics·Roger L NationAlexandre P Zavascki
Feb 23, 2021·ACS Applied Materials & Interfaces·Xingyue YangYumiao Zhang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Iranian Journal of Basic Medical Sciences
Sri Agus Sudjarwo Koerniasari
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
Feng XiaoHui Wang
© 2022 Meta ULC. All rights reserved