PMID: 15374375Jul 1, 1992Paper

Cytochrome P-450 catalytic activity and isoform composition following liver denervation in old male rats

Archives of Gerontology and Geriatrics
V V Frolkis, G I Paramonova

Abstract

A study was made concerning the role of adrenergic and cholinergic neural regulation in the functional activity of enzymes of microsomal oxidation in the liver. Experiments were performed on adult and old rats using surgical denervation of liver (vagotomy and sympathotomy). The results obtained showed changes that occurred in the monooxygenase activity (aminopyrine demethylase and aniline hydroxylase), as well as in the isoform composition and inductive synthesis of cytochrome P-450. The neural control over liver detoxication function was found to weaken in old age.

References

Jan 1, 1978·Experimental Gerontology·L S Birnbaum, M B Baird
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Feb 13, 1987·Biochemical and Biophysical Research Communications·W PyerinC R Wolf
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Apr 1, 1966·Journal of Gerontology·V V Frolkis
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Feb 1, 1981·Mechanisms of Ageing and Development·D L Schmucker, R K Wang
Jul 1, 1980·Toxicology and Applied Pharmacology·D N McMartinL S Kaminsky

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Citations

Oct 23, 2003·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Susan L MurphyThomas M Gill
Jun 24, 2017·Journal of Applied Gerontology : the Official Journal of the Southern Gerontological Society·Tuo-Yu ChenMegan Janke

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