Cytochrome P450 1A2 (CYP1A2) activity, mammographic density, and oxidative stress: a cross-sectional study

Breast Cancer Research : BCR
Chi-Chen HongN F Boyd

Abstract

Mammographically dense breast tissue is a strong predictor of breast cancer risk, and is influenced by both mitogens and mutagens. One enzyme that is able to affect both the mitogenic and mutagenic characteristics of estrogens is cytochrome P450 1A2 (CYP1A2), which is principally responsible for the metabolism of 17beta-estradiol. In a cross-sectional study of 146 premenopausal and 149 postmenopausal women, we examined the relationships between CYP1A2 activity, malondialdehyde (MDA) levels, and mammographic density. In vivo CYP1A2 activity was assessed by measuring caffeine metabolites in urine. Levels of serum and urinary MDA, and MDA-deoxyguanosine adducts in DNA were measured. Mammograms were digitized and measured using a computer-assisted method. CYP1A2 activity in postmenopausal women, but not in premenopausal women, was positively associated with mammographic density, suggesting that increased CYP1A2 activity after the menopause is a risk factor for breast cancer. In premenopausal women, but not in postmenopausal women, CYP1A2 activity was positively associated with serum and urinary MDA levels; there was also some evidence that CYP1A2 activity was more positively associated with percentage breast density when MDA levels...Continue Reading

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Citations

Feb 18, 2011·Breast Cancer Research and Treatment·Scott V AdamsJohanna W Lampe
Jun 20, 2006·Cancer Causes & Control : CCC·Anthony B CrestDiana S M Buist
Jun 12, 2008·Journal of the National Cancer Institute·Eva S SchernhammerPaola Muti
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Mar 2, 2016·Hormones & Cancer·Tess V ClendenenAnne Zeleniuch-Jacquotte
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Jan 24, 2021·Archives of Pharmacal Research·Yeo-Jung KwonYoung-Jin Chun
May 16, 2006·Journal of Inorganic Biochemistry·Victoria V ShumyantsevaAlexander I Archakov

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Methods Mentioned

BETA
hormone replacement therapy
MDA
hysterectomy
bilateral oophorectomy
blood draw
urine collection

Software Mentioned

SAS

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