Cytochrome P450 1B1, a novel chemopreventive target for benzo[a]pyrene-initiated human esophageal cancer

Cancer Letters
Xia Wen, Thomas Walle

Abstract

Esophageal cancer is common worldwide, with poor prognosis. Smoking, including exposure to polyaromatic hydrocarbons like benzo[a]pyrene (BaP), is a major risk factor. In human esophageal HET-1A cells, we found that time-dependent BaP-DNA binding was associated with upregulation of CYP1B1, but not CYP1A1, mRNA and protein. The dietary flavonoid 5,7-dimethoxyflavone significantly inhibited BaP-DNA binding and down-regulated BaP-induced CYP1B1 mRNA and protein. 3',4'-Dimethoxyflavone was an even more potent inhibitor of CYP1B1 expression, while resveratrol had no effect. Thus, dietary methoxylated flavones inhibited BaP-induced CYP1B1 transcription in a cell-specific manner and hold promise as chemopreventive agents in esophageal carcinogenesis.

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Citations

Jan 21, 2010·International Journal of Molecular Sciences·Thomas Walle
Dec 15, 2015·Journal of Pharmaceutical and Biomedical Analysis·Di Bei, Guohua An
Jul 12, 2008·Molecular Carcinogenesis·Andrea H DevlinStephanie R McKeown
Apr 25, 2015·Environmental Pollution·Martha Estela Salcido-NeyoyClaudia M García-Cuellar
Jun 19, 2007·Seminars in Cancer Biology·Thomas Walle
Sep 5, 2008·Expert Review of Vaccines·Thomas M Luby
Jul 20, 2007·The Journal of Pharmacy and Pharmacology·Thomas Walle, U Kristina Walle
Jul 27, 2006·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Xia Wen, Thomas Walle

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