PMID: 11927841Apr 3, 2002Paper

Cytochrome P450 2C9 polymorphisms: a comprehensive review of the in-vitro and human data

Pharmacogenetics
Craig R LeeJohn A Pieper

Abstract

The discovery of six distinct polymorphisms in the genetic sequence encoding for the cytochrome P450 2C9 (CYP2C9) protein has stimulated numerous investigations in an attempt to characterize their population distribution and metabolic activity. Since the CYP2C9*1, *2 and *3 alleles were discovered first, they have undergone more thorough investigation than the recently identified *4, *5 and *6 alleles. Population distribution data suggest that the variant *2 and *3 alleles are present in approximately 35% of Caucasian individuals; however, these alleles are significantly less prevalent in African-American and Asian populations. In-vitro data have consistently demonstrated that the CYP2C9*2 and *3 alleles are associated with significant reductions in intrinsic clearance of a variety of 2C9 substrates compared with CYP2C9*1; however, the degree of these reductions appear to be highly substrate-dependent. In addition, multiple in-vivo investigations and clinical case reports have associated genotypes expressing the CYP2C9*2 and *3 alleles with significant reductions in both the metabolism and daily dose requirements of selected CYP2C9 substrates. Individuals expressing these variant genotypes also appear to be significantly more s...Continue Reading

References

Jan 1, 1979·Diabetes·J Scott, P L Poffenbarger
Jun 1, 1985·Australian and New Zealand Journal of Medicine·J O MinersD J Birkett
Dec 1, 1994·Pharmacogenetics·J A Goldstein, S M de Morais
Apr 1, 1993·Pharmacogenetics·M E VeroneseD J Birkett
Jan 1, 1996·Methods in Enzymology·J O Miners, D J Birkett
Aug 1, 1996·Pharmacogenetics·T H Sullivan-KloseJ A Goldstein
Oct 1, 1996·Pharmacogenetics·M J StubbinsC R Wolf
Dec 1, 1996·British Journal of Clinical Pharmacology·W TassaneeyakulJ O Miners
Feb 1, 1997·Pharmacogenetics·C R BhaskerD J Birkett
Nov 14, 1997·Pharmacogenetics·D J StewardA E Rettie
Nov 14, 1997·Pharmacogenetics·K NasuT Ishizaki
Apr 29, 1998·Clinical Pharmacology and Therapeutics·K M WilliamsonJ A Pieper
Jul 15, 1998·British Journal of Clinical Pharmacology·J O Miners, D J Birkett
Jan 28, 1999·Biochemical and Biophysical Research Communications·U YasarF Sjöqvist
Mar 12, 1999·Lancet·P M Mannucci
Jul 21, 1999·Epilepsy Research·A E RettieR H Levy
Oct 6, 1999·Lancet·M S OggS E Humphries
Oct 6, 1999·British Journal of Clinical Pharmacology·A S AynaciogluI Roots
May 10, 2000·Pharmacogenetics·J O MinersJ A Goldstein
Apr 11, 2001·European Journal of Clinical Pharmacology·S MorinL Becquemont
Apr 12, 2001·British Journal of Clinical Pharmacology·Y R YoonJ G Shin
May 5, 2001·The New England Journal of Medicine·A J Wood

❮ Previous
Next ❯

Citations

Oct 7, 2003·European Journal of Drug Metabolism and Pharmacokinetics·Pedro DoradoAdrián Llerena
Aug 13, 2008·Analytical and Bioanalytical Chemistry·Ulrich M ZangerMatthias Schwab
Mar 19, 2005·European Journal of Clinical Pharmacology·Heydy V Bravo-VillaltaRyuya Horiuchi
Mar 26, 2009·European Journal of Clinical Pharmacology·D WernerT Rau
Jul 8, 2009·European Journal of Clinical Pharmacology·Masako OhnoJunichi Azuma
Aug 12, 2009·European Journal of Clinical Pharmacology·Melanie S JoyJoyce A Goldstein
Apr 9, 2011·European Journal of Clinical Pharmacology·Hee-Doo YooYong-Bok Lee
Aug 16, 2011·European Journal of Clinical Pharmacology·Chang-Ik ChoiSeok-Yong Lee
Jan 25, 2006·Journal of Human Genetics·Taisei MushirodaYusuke Nakamura
Jan 25, 2012·Journal of Pharmacokinetics and Pharmacodynamics·Kerenaftali KleinLeon Aarons
Sep 1, 2005·Journal of Thrombosis and Thrombolysis·Vivian W Y LeeGregory Cheng
Mar 4, 2009·Journal of General Internal Medicine·Mark H EckmanJonathan Rosand
Mar 24, 2009·Journal of General Internal Medicine·Kirsten Neudoerffer KangelarisJeffrey A Tice
May 22, 2013·Current Cardiology Reports·Peter Weeke, Dan M Roden
Nov 26, 2008·Neurocritical Care·Lauren K McCluggageMalcolm Ross Bullock
Mar 1, 2013·European Journal of Drug Metabolism and Pharmacokinetics·Ekta VarshneyShakir Ali
Apr 17, 2013·Molecular Diagnosis & Therapy·C F SamerJ A Desmeules
Jun 5, 2004·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Maria Gabriella ScordoEdoardo Spina
Apr 6, 2004·Trends in Pharmacological Sciences·Magnus Ingelman-Sundberg
Jun 5, 2003·Biochemical Pharmacology·Naomi MoritaKazuo Nakayama
Sep 23, 2003·Clinica Chimica Acta; International Journal of Clinical Chemistry·Z ZainuddinR Ismail
Sep 27, 2003·Toxicology·Munir Pirmohamed, B Kevin Park
Aug 4, 2004·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Andrew T ChanCharles S Fuchs
Aug 16, 2011·Acta Pharmacologica Sinica·Jung-woo BaeSeok-yong Lee
Feb 24, 2006·Nature Reviews. Cancer·Cornelia M UlrichJohn D Potter
Oct 13, 2006·Nature Reviews. Cancer·Vered StearnsDavid A Flockhart
Apr 22, 2009·The Pharmacogenomics Journal·Paula Sánchez-DizAdolfo Figueiras
Oct 10, 2012·The Pharmacogenomics Journal·J E WyattS Harirforoosh
May 27, 2005·The New England Journal of Medicine·Grant R Wilkinson
Nov 17, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Robert C Owens, Thomas D Nolin
Feb 1, 2012·Genetic Testing and Molecular Biomarkers·Seyed Mohammad Bagher Hashemi-SotehMohammad-Reza Shiran
Oct 13, 2005·Pharmacogenetics and Genomics·Aurel C AllabiYves Horsmans
Jun 22, 2006·Pharmacogenetics and Genomics·Keiko MaekawaJun-ichi Sawada
Feb 17, 2005·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Simon SandersonJulian Higgins
Feb 13, 2010·Pharmacogenetics and Genomics·Derek Van BoovenRuss B Altman
Dec 3, 2009·Pharmacogenetics and Genomics·Elizabeth M AzzatoNeil E Caporaso
Feb 18, 2012·Pharmacogenetics and Genomics·Li GongTeri E Klein

❮ Previous
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