Jan 15, 2009

Cytochrome P450 2E1 expression in mice liver after exposure to continuous and acute gamma-radiation

Ukrainskiĭ biokhimicheskiĭ zhurnal
O V MaksymchukM O Chashchyn


The effect of continuous low-intensity and acute high-intensity ionizing radiation in low and high doses on expression of cytochrome P450 2El ( in mice liver was studied. It was shown, that changes of Cyp2e1 amount depended on the dose and intensity of ionizing radiation. Low doses of continuous gamma-radiation caused reliable decrease of Cyp2e1 expression on protein mRNA levels. Low doses of acute gamma-radiation lead to an increase of Cyp2el amount, while high doses--to a corresponding decrease. We showed, that low and high doses of acute gamma-radiation caused a significant decrease of Cyp2e1 mRNA level. We suppose that the detected changes of Cyp2el expression are associated with peroxidation process and development of oxidative stress.

  • References
  • Citations


  • We're still populating references for this paper, please check back later.
  • References
  • Citations


  • This paper may not have been cited yet.

Mentioned in this Paper

Electrophoresis, Agar Gel
Mice, Inbred BALB C
Cytochrome P450
CYP2E1 gene
Oxidative Stress
Oxidative Stress Analysis
Gene Expression
Cytochrome P-450 CYP2E1
Western Blot
Dose-Response Relationship, Radiation

About this Paper

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Bone Marrow Neoplasms

Bone Marrow Neoplasms are cancers that occur in the bone marrow. Discover the latest research on Bone Marrow Neoplasms here.

IGA Glomerulonephritis

IgA glomerulonephritis is a chronic form of glomerulonephritis characterized by deposits of predominantly Iimmunoglobin A in the mesangial area. Discover the latest research on IgA glomerulonephritis here.

Cryogenic Electron Microscopy

Cryogenic electron microscopy (Cryo-EM) allows the determination of biological macromolecules and their assemblies at a near-atomic resolution. Here is the latest research.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

LRRK2 & Immunity During Infection

Mutations in the LRRK2 gene are a risk-factor for developing Parkinson’s disease. However, LRRK2 has been shown to function as a central regulator of vesicular trafficking, infection, immunity, and inflammation. Here is the latest research on the role of this kinase on immunity during infection.

Antiphospholipid Syndrome

Antiphospholipid syndrome or antiphospholipid antibody syndrome (APS or APLS), is an autoimmune, hypercoagulable state caused by the presence of antibodies directed against phospholipids.

Meningococcal Myelitis

Meningococcal myelitis is characterized by inflammation and myelin damage to the meninges and spinal cord. Discover the latest research on meningococcal myelitis here.

Alzheimer's Disease: MS4A

Variants within membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease by recent genome-wide association studies. Here is the latest research.