Jan 15, 2009

Cytochrome P450 2E1 expression in mice liver after exposure to continuous and acute gamma-radiation

Ukrainskiĭ biokhimicheskiĭ zhurnal
O V MaksymchukM O Chashchyn

Abstract

The effect of continuous low-intensity and acute high-intensity ionizing radiation in low and high doses on expression of cytochrome P450 2El (1.14.14.1) in mice liver was studied. It was shown, that changes of Cyp2e1 amount depended on the dose and intensity of ionizing radiation. Low doses of continuous gamma-radiation caused reliable decrease of Cyp2e1 expression on protein mRNA levels. Low doses of acute gamma-radiation lead to an increase of Cyp2el amount, while high doses--to a corresponding decrease. We showed, that low and high doses of acute gamma-radiation caused a significant decrease of Cyp2e1 mRNA level. We suppose that the detected changes of Cyp2el expression are associated with peroxidation process and development of oxidative stress.

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Mentioned in this Paper

Electrophoresis, Agar Gel
Mice, Inbred BALB C
Cytochrome P450
CYP2E1 gene
Oxidative Stress
Oxidative Stress Analysis
Gene Expression
Cytochrome P-450 CYP2E1
Western Blot
Dose-Response Relationship, Radiation

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