Cytochrome P450 2J2*7 polymorphisms in Japanese, Mongolians and Ovambos

Cell Biochemistry and Function
Haruo TakeshitaJunko Fujihara

Abstract

Human cytochrome P450 2J2 (CYP2J2) is abundant in cardiovascular tissue and active in the metabolism of arachidonic acid to eicosanoids that have potent vasodilatory properties. Variability of the CYP2J2 gene is highly constrained except for its proximal promoter: there is a relatively common and functionally relevant single nucleotide polymorphism, indicated by -50G > T polymorphism (CYP2J2*7). Although genetic variation is known among ethnic groups, data for allele frequency are limited to a few Caucasian, Asian, and one African populations. In the present study, genotype distribution of CYP2J2*7 polymorphisms was investigated using polymerase chain reaction and restriction fragment length polymorphism assay in Japanese (n = 338), Mongolian (n = 118), and Ovambo (n = 186) populations and the findings compared with other populations. The mutant (CYP2J2*7) frequencies in the Japanese, Mongolians, and Ovambos were 0.0621, 0.0339, and 0.0672, respectively. Except for the Taiwanese, a general uniformity in the polymorphism in the Asian populations was observed. The mutation frequency of Ovambos was relatively lower than that of the African-American population. This study is the first to investigate the distribution of the CYP2J2*7...Continue Reading

References

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Citations

Jun 27, 2012·Genetic Testing and Molecular Biomarkers·Abdullah AlghashamAhmad A Settin
Aug 27, 2010·Pharmacogenetics and Genomics·Dorit S BerlinRuss B Altman
Jan 23, 2010·Pharmacology & Therapeutics·Beshay N M Zordoky, Ayman O S El-Kadi

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