Cytochrome P450 3A gene variation, steroid hormone serum levels and prostate cancer--The Rotterdam Study

Steroids
Claire SiemesRon H N van Schaik

Abstract

To study if polymorphisms in genes encoding for CYP3A enzymes, that play a role in steroid hormone metabolism, affect steroid hormone serum levels and prostate cancer incidence or mortality. 3048 male participants of The Rotterdam Study were included. Prostate cancer cases and non-cases were studied for differences in baseline hormone levels with Student's t-test. General linear models were performed on different random subsets of hormone levels to study associations with genotype. Cox' proportional hazard models were used to study prostate cancer incidence and mortality among genotypes. Both DHEAS sulphate as free-testosterone were significantly increased at baseline in males who developed a prostate cancer within the study period. CYP3A4 G-allele carriage was associated with lower levels of estrone sulphate (p=0.005) and higher levels of estradiol (p=0.04) compared to non-carriers. CYP3A5 A-allele carriage was associated with increased levels of estrone sulphate (p=0.02). CYP3A7 G-allele carriage was associated with the highest number of significant differences in steroid hormone levels. Carriers of the allele resulting in continued enzyme expression during adulthood had decreased levels of dehydroepiandrosterone (DHEA) sulph...Continue Reading

Citations

Aug 31, 2011·European Journal of Epidemiology·Albert HofmanJacqueline C M Witteman
Jul 3, 2015·International Journal of Molecular Sciences·Zi-Ru DaiLing Yang
Aug 23, 2012·Steroids·Haq Nawaz Bhatti, Rasheed Ahmad Khera
Aug 12, 2014·The Prostate·Anna M JohnsonKathleen A Cooney
Jul 26, 2011·Molecular and Cellular Endocrinology·Johanna Schleutker
Aug 26, 2014·Journal of Neural Transmission·Eva J BrandlDaniel J Müller
Jan 21, 2014·Molecular Biology Reports·Fabiana B KohlrauschMara H Hutz
Jun 21, 2013·Cellular and Molecular Life Sciences : CMLS·Marine BaptissartDavid H Volle

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Incidence & Mortality

Cancer has emerged as a global concern due to its increase in incidence and mortality. Efforts are underway to evaluate and develop action plans to reduce the global burden of cancer. Currently, lung cancer, breast cancer and prostate cancer are the leading causes of cancer mortality. Here is the latest research on cancer incidence and mortality.

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.