Cytochrome P450 activity and its alteration in different diseases

Revista médica de Chile
Myriam Orellana, Viviana Guajardo

Abstract

Cytochrome P450 (CYP) enzymes participate in the metabolism of a variety of naturally occurring and foreign compounds by reactions requiring NADPH and O2. The diversity of reactions catalyzed and its extensive substrate specificity render CYP enzymes as one of the most versatile known catalysts. Individual members of the CYP superfamily are expressed in almost every cell type in the body. As compared to hepatic enzymes, the regulation of human extrahepatic CYPs has not been so well studied. In general, the levels of some hepatic CYP enzymes are depressed by diseases, causing potential and documented impairment of drug clearence and clinical drug toxicity. However, modulation of CYPs is enzyme selective and this selectivity differs in different diseases. This article reviews some basic concepts about CYP and its regulation in some disease states such as hypertension, diabetes, obesity and hepatic, infectious and inflammatory diseases.

Citations

Apr 25, 2020·Frontiers in Nutrition·Helena Jenzer, Leila Sadeghi-Reeves
Apr 15, 2010·Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering·Julian Rios-SicairosAlejandra Garcia-Gasca
Jun 27, 2014·Annals of Dermatology·Abdullateef A AlzolibaniAhmed A Settin
Oct 18, 2016·Drug Safety - Case Reports·Claudia Reynoso-von DratelnCarlos Torres-Lozano

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