Cytochrome P450 diversity in the tree of life

Biochimica Et Biophysica Acta. Proteins and Proteomics
David R Nelson

Abstract

Sequencing in all areas of the tree of life has produced >300,000 cytochrome P450 (CYP) sequences that have been mined and collected. Nomenclature has been assigned to >41,000 CYP sequences and the majority of the remainder has been sorted by BLAST searches into clans, families and subfamilies in preparation for naming. The P450 sequence space is being systematically explored and filled in. Well-studied groups like vertebrates are covered in greater depth while new insights are being added into uncharted territories like horseshoe crab (Limulus polyphemus), tardigrades (Hypsibius dujardini), velvet worm (Euperipatoides_rowelli), and basal land plants like hornworts, liverworts and mosses. CYPs from the fungi, one of the most diverse groups, are being explored and organized as nearly 800 fungal species are now sequenced. The CYP clan structure in fungi is emerging with 805 CYP families sorting into 32 CYP clans. >3000 bacterial sequences are named, mostly from terrestrial or freshwater sources. Of 18,379 bacterial sequences downloaded from the CYPED database, all are >43% identical to named CYPs. Therefore, they fit in the 602 named P450 prokaryotic families. Diversity in this group is becoming saturated, however 25% of 3305 sea...Continue Reading

References

May 1, 1981·Prostaglandins·M ClaeysD H Nugteren
May 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·Y Fujii-KuriyamaM Muramatsu
Aug 27, 1999·Archives of Biochemistry and Biophysics·D R Nelson
Mar 25, 2000·Science·M D AdamsJ C Venter
Feb 28, 2007·BMC Evolutionary Biology·Jixin DengRalph A Dean
Jan 1, 2008·The Veterinary Clinics of North America. Exotic Animal Practice·Ricardo de Matos
Jul 6, 2010·Biochimica Et Biophysica Acta·R Feyereisen
Mar 30, 2011·The Plant Journal : for Cell and Molecular Biology·David Nelson, Danièle Werck-Reichhart
Oct 2, 2012·The Journal of Eukaryotic Microbiology·Sina M AdlFrederick W Spiegel
Dec 4, 2013·Nucleic Acids Research·Igor V GrigorievIgor Shabalov
Dec 21, 2013·Science·UNKNOWN Amborella Genome Project
Feb 15, 2014·Molecular Phylogenetics and Evolution·Mariela L TomazicAlejandro D Nusblat
Oct 31, 2014·Proceedings of the National Academy of Sciences of the United States of America·Norman J WickettJames Leebens-Mack
Jan 28, 2015·GigaScience·Naim MatasciGane Ka-Shu Wong
Apr 30, 2015·PloS One·Michael A RuggieroPaul M Kirk
May 25, 2015·Trends in Genetics : TIG·Stephen Richards
Jul 2, 2015·Scientific Reports·Mopeli Marshal SelloKhajamohiddin Syed
Apr 2, 2016·Proceedings of the National Academy of Sciences of the United States of America·Georgios KoutsovoulosMark Blaxter
May 24, 2016·Current Biology : CB·Ricardo J LopesMiguel Carneiro

❮ Previous
Next ❯

Citations

Jun 1, 2018·International Journal of Molecular Sciences·Philippe UrbanGilles Truan
Oct 21, 2018·Planta·Linhong TengNaihao Ye
Jan 31, 2019·Chemistry : a European Journal·Jiakun XuZhiqi Cong
Jun 5, 2019·International Journal of Molecular Sciences·Puleng Rosinah SyedKhajamohiddin Syed
Dec 21, 2019·Applied Microbiology and Biotechnology·Razak HussainYusuf Akhter
Dec 8, 2019·The Journal of Biological Chemistry·Zhong LiWei Zhang
Aug 11, 2019·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Sheila Cardeña-NúñezMatías Hidalgo-Sánchez
Jan 11, 2020·Chembiochem : a European Journal of Chemical Biology·Rosa A LuirinkDaan P Geerke
Jun 13, 2018·International Journal of Molecular Sciences·Mathula Lancelot NgwenyaKhajamohiddin Syed
Nov 6, 2018·Cold Spring Harbor Protocols·Bob Goldstein
Nov 21, 2018·International Journal of Molecular Sciences·Bongumusa Comfort MthethwaKhajamohiddin Syed
Aug 7, 2019·Applied Microbiology and Biotechnology·Rosa E CardozaSantiago Gutiérrez
Jul 12, 2020·International Journal of Molecular Sciences·Nokwanda Samantha NgcoboKhajamohiddin Syed
Mar 3, 2019·International Journal of Molecular Sciences·Lydia BenkaidaliMichel Petitjean
Apr 2, 2020·Nature Reviews. Chemistry·Thomas A Scott, Jörn Piel
Sep 5, 2020·Biophysics Reviews·Zinhle Edith ChilizaKhajamohiddin Syed
May 30, 2020·Antioxidants·Balaji Aravindhan PandianMithila Jugulam
Jun 24, 2020·Applied Microbiology and Biotechnology·Hongjae Park, In-Geol Choi
Jun 7, 2019·Proceedings of the National Academy of Sciences of the United States of America·David C LambJohn J Stegeman
Jul 11, 2020·International Journal of Molecular Sciences·Fanele Cabangile MnguniKhajamohiddin Syed
Mar 10, 2019·Scientific Reports·Louisa Moshoeshoe SenateKhajamohiddin Syed
Oct 5, 2020·FEBS Letters·Paolo Riccio, Rocco Rossano
Nov 10, 2020·Protein Science : a Publication of the Protein Society·Stephen G Sligar, Ilia G Denisov
Nov 7, 2019·Pesticide Biochemistry and Physiology·Keon Mook SeongBarry R Pittendrigh
Dec 6, 2019·Archives of Biochemistry and Biophysics·Florian A ThesselingMarco Girhard
Jun 20, 2020·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Morgan E ChaneyAnthony J Tosi
May 16, 2020·Trends in Biochemical Sciences·Giovanna Di Nardo, Gianfranco Gilardi
Mar 13, 2021·Natural Product Reports·Xingwang ZhangShengying Li
Mar 7, 2020·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Yu-Jie ZhaoNai-Yong Liu
Mar 24, 2021·Biological Reviews of the Cambridge Philosophical Society·Yiwen WangBernard Moussian
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ntombizethu Nokuphiwa MsomiKhajamohiddin Syed
Apr 17, 2021·Genes & Development·Hua Yan, Jürgen Liebig
Apr 21, 2021·Current Opinion in Insect Science·May Berenbaum, Bernarda Calla
May 4, 2021·Frontiers in Microbiology·James B Y H Behrendorff
Apr 29, 2021·Biotechnology Journal·Shishir SharmaMatthias Bureik

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bioinformatics in Biomedicine

Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest research on bioinformatics in biomedicine here.

Archaeogenetics

Recent advances in genomic sequencing has led to the discovery of new strains of Archaea and shed light on their evolutionary history. Discover the latest research on Archaeogenetics here.