Cytochrome P450 eicosanoids in cerebrovascular function and disease

Pharmacology & Therapeutics
Catherine M DavisN J Alkayed

Abstract

Cytochrome P450 eicosanoids play important roles in brain function and disease through their complementary actions on cell-cell communications within the neurovascular unit (NVU) and mechanisms of brain injury. Epoxy- and hydroxyeicosanoids, respectively formed by cytochrome P450 epoxygenases and ω-hydroxylases, play opposing roles in cerebrovascular function and in pathological processes underlying neural injury, including ischemia, neuroinflammation and oxidative injury. P450 eicosanoids also contribute to cerebrovascular disease risk factors, including hypertension and diabetes. We summarize studies investigating the roles P450 eicosanoids in cerebrovascular physiology and disease to highlight the existing balance between these important lipid signaling molecules, as well as their roles in maintaining neurovascular homeostasis and in acute and chronic neurovascular and neurodegenerative disorders.

References

Oct 27, 2016·Ageing Research Reviews·Tuo YangFeng Zhang
Dec 3, 2016·Clinical Science·Mariela MitreMoses V Chao

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Citations

Mar 29, 2019·Expert Opinion on Therapeutic Targets·Yuanyuan Cheng, Jianhui Rong
Feb 28, 2018·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Xiaoning HanJian Wang
Aug 23, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Clara Dos Reis NunesDaniela Barros de Oliveira
Jun 15, 2020·Pharmacology & Therapeutics·Aditi DasHannah C Huff
Apr 16, 2021·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Wenri ZhangNabil J Alkayed
Feb 5, 2019·Biochimie·Sean D Kodani, Christophe Morisseau
Jun 3, 2021·International Journal of Molecular Sciences·Catherine M DavisNabil J Alkayed
Jun 16, 2021·International Journal of Radiation Biology·Marjan BoermaJacqueline P Williams

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