Cytochrome P4501A1 is required for vascular dysfunction and hypertension induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin.

Toxicological Sciences : an Official Journal of the Society of Toxicology
Phillip G KopfMary K Walker

Abstract

National Health and Nutrition Examination Survey data show an association between hypertension and exposure to dioxin-like halogenated aromatic hydrocarbons (HAHs). Furthermore, chronic exposure of mice to the prototypical HAH, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), induces reactive oxygen species (ROS), endothelial dysfunction, and hypertension. Because TCDD induces cytochrome P4501A1 (CYP1A1) and CYP1A1 can increase ROS, we tested the hypothesis that TCDD-induced endothelial dysfunction and hypertension are mediated by CYP1A1. CYP1A1 wild-type (WT) and knockout (KO) mice were fed one control or TCDD-containing pill (180 ng TCDD/kg, 5 days/week) for 35 days (n = 10-14/genotype/treatment). Blood pressure was monitored by radiotelemetry, and liver TCDD concentration, CYP1A1 induction, ROS, and aortic reactivity were measured at 35 days. TCDD accumulated to similar levels in livers of both genotypes. TCDD induced CYP1A1 in endothelium of aorta and mesentery without detectable expression in the vessel wall. TCDD also induced superoxide anion production, measured by NADPH-dependent lucigenin luminescence, in aorta, heart, and kidney of CYP1A1 WT mice but not KO mice. In contrast, TCDD induced hydrogen peroxide, measured by amp...Continue Reading

References

Aug 1, 1995·Journal of Biochemical Toxicology·M ToborekB Hennig
Jun 15, 1996·Archives of Biochemistry and Biophysics·S A KraemerD L DeWitt
Jan 7, 2000·Biochemical and Biophysical Research Communications·T P DaltonD W Nebert
Apr 26, 2000·Genome Research·M StollH J Jacob
May 16, 2001·Toxicological Sciences : an Official Journal of the Society of Toxicology·J J DilibertoL S Birnbaum
Sep 6, 2002·Cardiovascular Toxicology·T P DaltonA Puga
Sep 18, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Sean P DidionFrank M Faraci
Apr 25, 2003·Biochemical and Biophysical Research Communications·Hiroki TeraokaTakeo Hiraga
Feb 24, 2004·Molecular Pharmacology·Jennifer H GrayKathleen M Giacomini
Feb 26, 2004·Free Radical Biology & Medicine·Howard G ShertzerTimothy P Dalton
Sep 15, 2004·Toxicology and Applied Pharmacology·Richard C ZangarSeema Verma
Jun 2, 2005·In Vitro Cellular & Developmental Biology. Animal·Rita Anne GarrickJohn J Stegeman
Sep 29, 2006·American Journal of Industrial Medicine·Han K KangGenevieve M Matanoski
Nov 6, 2007·Journal of the American College of Cardiology·Marc A Silver, Clyde W Yancy
Sep 27, 2008·Environmental Research·C J EverettE M Matheson
Dec 30, 2008·Pharmacological Reviews·Christopher S Wilcox, Adam Pearlman
Jan 6, 2009·Reviews on Environmental Health·Timothy E O'TooleAruni Bhatnagar
Jan 8, 2009·Cardiovascular Research·Daniel E ConwayLarry V McIntire
Feb 17, 2009·Experimental Physiology·Danielle SenadorKhalid M Elased
May 13, 2009·Hypertension·Hana ItaniCurt D Sigmund

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Citations

Aug 29, 2012·Archives of Toxicology·Paul JenningsMartin O Leonard
May 24, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Wataru YoshiokaChiharu Tohyama
Sep 13, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Michael S DenisonBin Zhao
Mar 19, 2013·Environmental Science and Pollution Research International·Katryn EskeBernhard Hennig
Apr 17, 2015·Environmental Science and Pollution Research International·Jordan T PerkinsBernhard Hennig
Feb 14, 2012·Toxicology and Applied Pharmacology·Mary K WalkerLinda A Felton
Aug 19, 2011·Toxicology and Applied Pharmacology·Hong LuCurtis D Klaassen
Mar 5, 2016·International Journal of Environmental Research and Public Health·Hye Ah LeeHyesook Park
Dec 21, 2010·The Journal of Steroid Biochemistry and Molecular Biology·Wataru YoshiokaChiharu Tohyama
Feb 18, 2014·Environmental Research·P Monica LindLars Lind
Dec 3, 2014·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Nguyen T K VoNiels C Bols
Oct 30, 2016·Toxicological Sciences : an Official Journal of the Society of Toxicology·Elani F WiestMary K Walker
Nov 8, 2016·Journal of Occupational and Environmental Medicine·Yasmin S CypelVictoria J Davey
Mar 1, 2018·Frontiers in Immunology·Ping XueYufeng Zhou
Oct 16, 2014·The Journal of Pharmacology and Experimental Therapeutics·Larry N AgborMary K Walker
Jun 20, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Shumin GuoJian Zhang
Dec 6, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Nicole J Gentner, Lynn P Weber
Jan 9, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Nuno R CoelhoEmília C Monteiro

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